Linzolid 400 mg (Tablet)
Unit Price: ৳ 60.00 (1 x 10: ৳ 600.00)
Strip Price: ৳ 600.00
Medicine Details
Category | Details |
---|---|
Generic | Linezolid |
Company | Incepta pharmaceuticals ltd |
Also available as |
Indications
- Treatment of Nosocomial pneumonia
- Treatment of Community-acquired pneumonia
- Treatment of Complicated skin and skin structure infection
- Treatment of Uncomplicated skin and skin structure infections
- Treatment of Vancomycin-resistant Enterococcus faecium infections
- Not indicated for Gram-negative infections
Pharmacology
- Belongs to the class of oxazolidinones
- In vitro activity against Gram positive aerobic bacteria
- Selectively inhibits bacterial protein synthesis
- Binds to 23S ribosomal RNA of the 50S subunit
- Prevents the formation of a functional 70S initiation complex
Dosage & Administration
- Available in oral tablets and IV infusion form
- Oral tablets can be taken with or without food
- IV infusion should be administered over a period of 30 to 120 minutes
- Dosage varies for different infections
- No dose adjustment necessary when switching from intravenous to oral administration
Drug Interactions
- Reversible, nonselective inhibitor of monoamine oxidase
- Potential interaction with adrenergic and serotonergic agents
- Enhancement of the pressor response
- Advice patients to avoid large quantities of foods or beverages with high tyramine content
Contraindications
- Contraindicated for patients with known hypersensitivity to Linezolid
- Should not be used with monoamine oxidase inhibitors
- Not recommended for patients with uncontrolled hypertension or specific medical conditions
Side Effects
- Most adverse events reported were mild to moderate in intensity
- Common adverse events include diarrhea, headache, and nausea
- Other adverse events include hypertension, dyspepsia, and pruritus
Pregnancy & Lactation
- No identified drug-associated risk of major birth defects or miscarriage
- Presence in breast milk, with potential effects on breastfed child
- Consideration of maternal need for linezolid and potential effects on breastfed child
Precautions & Warnings
- Regular monitoring of complete blood counts
- Prompt ophthalmic evaluation if visual impairment symptoms occur
- Not approved for catheter-related bloodstream infections
- Careful monitoring for potential increases in blood pressure
- Immediate medical evaluation for certain symptoms such as nausea or vomiting
Overdose Effects
- No reported cases of overdose
- Symptomatic and supportive care advised
- Approximately 30% of a Linzolid dose removed during 3 hours of haemodialysis
Therapeutic Class
- Belongs to the macrolides therapeutic class
Reconstitution
- Oral suspension reconstitution process described
- IV Injection supplied in ready-to-use infusion bottles
- Storage and usage instructions for reconstituted suspension
Storage Conditions
- Storage at room temperature (15°C-30°C), away from light and moisture
- All medicines should be kept away from children
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