Linzolid 400 mg (Tablet)

Unit Price: ৳ 60.00 (1 x 10: ৳ 600.00)
Strip Price: ৳ 600.00

Medicine Details

Category Details
Generic Linezolid
Company Incepta pharmaceuticals ltd
Also available as
Linzolid 600 mg tablet Linzolid 100 mg suspension Linzolid 2 mg injection

Indications

  • Treatment of Nosocomial pneumonia
  • Treatment of Community-acquired pneumonia
  • Treatment of Complicated skin and skin structure infection
  • Treatment of Uncomplicated skin and skin structure infections
  • Treatment of Vancomycin-resistant Enterococcus faecium infections
  • Not indicated for Gram-negative infections

Pharmacology

  • Belongs to the class of oxazolidinones
  • In vitro activity against Gram positive aerobic bacteria
  • Selectively inhibits bacterial protein synthesis
  • Binds to 23S ribosomal RNA of the 50S subunit
  • Prevents the formation of a functional 70S initiation complex

Dosage & Administration

  • Available in oral tablets and IV infusion form
  • Oral tablets can be taken with or without food
  • IV infusion should be administered over a period of 30 to 120 minutes
  • Dosage varies for different infections
  • No dose adjustment necessary when switching from intravenous to oral administration

Drug Interactions

  • Reversible, nonselective inhibitor of monoamine oxidase
  • Potential interaction with adrenergic and serotonergic agents
  • Enhancement of the pressor response
  • Advice patients to avoid large quantities of foods or beverages with high tyramine content

Contraindications

  • Contraindicated for patients with known hypersensitivity to Linezolid
  • Should not be used with monoamine oxidase inhibitors
  • Not recommended for patients with uncontrolled hypertension or specific medical conditions

Side Effects

  • Most adverse events reported were mild to moderate in intensity
  • Common adverse events include diarrhea, headache, and nausea
  • Other adverse events include hypertension, dyspepsia, and pruritus

Pregnancy & Lactation

  • No identified drug-associated risk of major birth defects or miscarriage
  • Presence in breast milk, with potential effects on breastfed child
  • Consideration of maternal need for linezolid and potential effects on breastfed child

Precautions & Warnings

  • Regular monitoring of complete blood counts
  • Prompt ophthalmic evaluation if visual impairment symptoms occur
  • Not approved for catheter-related bloodstream infections
  • Careful monitoring for potential increases in blood pressure
  • Immediate medical evaluation for certain symptoms such as nausea or vomiting

Overdose Effects

  • No reported cases of overdose
  • Symptomatic and supportive care advised
  • Approximately 30% of a Linzolid dose removed during 3 hours of haemodialysis

Therapeutic Class

  • Belongs to the macrolides therapeutic class

Reconstitution

  • Oral suspension reconstitution process described
  • IV Injection supplied in ready-to-use infusion bottles
  • Storage and usage instructions for reconstituted suspension

Storage Conditions

  • Storage at room temperature (15°C-30°C), away from light and moisture
  • All medicines should be kept away from children

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