Loril 50 mg (Tablet)
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Astra biopharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in vascular smooth muscle, adrenal gland, kidneys, and heart
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily for most patients
- Recommended 25 mg twice daily if 50 mg once daily is inadequate
- Starting dose of 25 mg once daily for intravascular volume-depleted patients
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose of 25 mg once daily recommended for patients over 75 years
Interaction
- Rifampicin and fluconazole reduce levels of active metabolite
- Concomitant use with hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use with potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may increase serum potassium levels
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with concomitant use of ACE-inhibitor, angiotensin receptor antagonist, anti-inflammatory drug, and thiazide diuretic
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component of the product
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased fetal risk if administered during the second or third trimesters
Precautions & Warnings
- Reduces fetal renal function and increases fetal and neonatal morbidity and death during the second and third trimesters of pregnancy
- Symptomatic hypotension may occur in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Reported changes in renal function and renal failure in renal-impaired patients
Use in Special Populations
- No initial dosage adjustment for patients with mild renal impairment (creatinine clearance 20-50 ml/min)
- Lower starting dose recommended for moderate to severe renal impairment or patients on dialysis
- Lower dose recommended for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children