Loril 100 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Astra biopharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose of 25 mg once daily for patients over 75 years
- No initial dosage adjustment for patients upto 75 years
Interaction
- Rifampicin and fluconazole reduce active metabolite levels
- Concomitant use with hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use with potassium-sparing diuretics or supplements may increase serum potassium
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with concurrent use of certain drugs
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk increases if administered during second or third trimesters
- Not known whether excreted in human milk
- Potential adverse effects on nursing infant
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment necessary in patients with mild renal impairment
- Lower starting dose recommended for moderate to severe renal impairment or patients on dialysis
- Lower dose considered for patients with hepatic impairment
Therapeutic Class
- Angiotensin-ll receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children