Losapress 50 mg (Tablet)
Unit Price: ৳ 9.00 (5 x 10: ৳ 450.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Benham pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily if 50 mg once daily is inadequate
- 25 mg once daily for patients with intravascular volume-depletion
Interaction
- Reduction of active metabolite levels by Rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Risk of increased serum potassium with potassium-sparing diuretics
- Attenuation of antihypertensive effect by indomethacin
Contraindications
- Pregnant women
- Hypersensitivity to any component
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Dizziness
- Diarrhea
- Nasal congestion
- Cough
- Fatigue
- Edema
- Abdominal pain
- Chest pain
- Nausea
- Headache
- Pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to the fetus if administered during second or third trimester
- Unknown excretion in human milk
Precautions & Warnings
- Reduction of fetal renal function and increase in fetal and neonatal morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Increased plasma concentration in cirrhotic patients
- Reports of changes in renal function including renal failure in renal-impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Lower dose for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children