Preslow 25 mg (Tablet)
Unit Price: ৳ 4.51 (5 x 10: ৳ 225.50)
Strip Price: ৳ 45.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Labaid pharma ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg
- Option for combination with other antihypertensive agents
- Different dosages for patients under 75 years and over 75 years
Interaction
- Reduction of active metabolite levels by rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Potential increase in serum potassium levels with potassium-sparing diuretics
Contraindications
- Contraindicated in pregnant women
- Not to be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion
- Other potential side effects such as fatigue, edema, and abdominal pain
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus if administered during second or third trimesters
- Unknown excretion in human milk
Precautions & Warnings
- Reduced fetal renal function and increased fetal morbidity in second and third trimesters
- Symptomatic hypotension in volume-depleted patients
- Plasma concentration increase in cirrhotic patients
Use in Special Populations
- No initial dosage adjustment in mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Consideration of lower dose for patients with hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children