Pertilos 50 mg (Tablet)
Unit Price: ৳ 8.03 (3 x 10: ৳ 240.90)
Strip Price: ৳ 80.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Navana pharmaceuticals ltd |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction
- Reduces release of aldosterone responsible for hypertension
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily for most patients
- Additional dosage recommendation for patients with intravascular volume-depletion
- Lower starting dose of 25 mg once daily for patients over 75 years
- Total daily dose ranges from 25 mg to 100 mg
Interaction
- Reduction of active metabolite levels with rifampicin and fluconazole
- Potentiation of antihypertensive effects with concomitant use of hydrochlorothiazide
- Increased serum potassium with potassium-sparing diuretics, potassium supplements, or salt substitutes
- Attenuation of antihypertensive effect by non-steroidal anti-inflammatory drug indomethacin
- Increased risk of renal impairment with the use of multiple drugs simultaneously
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component of the product
- Contraindicated with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased risk to the fetus if administered during the second or third trimesters of pregnancy
- Uncertain excretion in human milk
- Potential adverse effects on the nursing infant
Precautions & Warnings
- Reduction of fetal renal function and increase in fetal and neonatal morbidity and mortality with use during second and third trimesters of pregnancy
- Risk of symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function and renal failure reported in renal-impaired patients
Use in Special Populations
- No initial dosage adjustment necessary in patients with mild renal impairment (creatinine clearance 20-50 ml/min)
- Lower starting dose recommended for patients with moderate to severe renal impairment (creatinine clearance <20 ml/min) or patients on dialysis
- Lower dose consideration for patients with a history of hepatic impairment
- Contraindicated in pregnancy and in patients hypersensitive to losartan
- Potential increase in blood urea and serum creatinine with other drugs affecting the renin-angiotensin-aldosterone system in patients with bilateral renal artery stenosis or solitary kidney
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children