SB-Losak 25 mg (Tablet)
Unit Price: ৳ 4.50 (50's pack: ৳ 225.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Sunman birdem pharma ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- Variation in dosage for patients with intravascular volume-depletion
- Dosage adjustment for patients over 75 years
Interaction
- Reduction of active metabolite levels by rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Increase in serum potassium levels with potassium-sparing diuretics
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Contraindicated with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased risk to fetus in second or third trimester
- Potential excretion in human milk
Precautions & Warnings
- Reduction in fetal renal function and increase in fetal and neonatal morbidity and death
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function and renal failure in renal impaired patients
Use in Special Populations
- Dosage considerations for patients with renal impairment
- Lower starting dose for patients with moderate to severe renal impairment
- Consideration of lower dose for patients with hepatic impairment
Therapeutic Class
- Angiotensin II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children