Angitan Plus 50 mg+12.5 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
Category | Details |
---|---|
Generic | Losartan potassium hydrochlorothiazide |
Company | Chemist laboratories ltd |
Indications
- Treatment of hypertension
- Risk reduction of stroke in patients with hypertension and left ventricular hypertrophy
Pharmacology
- Angiotensin II vasoconstrictor
- Aldosterone secretion stimulator
- Thiazide diuretic effect
- Renal tubular electrolyte reabsorption modifier
Dosage
- Usual starting dose of 50/12.5 is one tablet once daily
- Maximum dosage of 100/25 once daily
- Antihypertensive effect attained within three weeks
- No initial dosage adjustment needed for elderly patients
Administration
- May be administered with other antihypertensive agents
- May be administered with or without food
Interaction
- No significant drug-drug interactions found with Hydrochlorothiazide, Digoxin, Warfarin, Cimetidine and Phenobarbital
- Potential interaction with potassium-sparing diuretics, potassium supplements, or salt substitutes
- Interaction with alcohol, barbiturates, or narcotics causing potentiation of orthostatic hypotension
- Interaction with antidiabetic drugs requiring dosage adjustment
- Additive effect or potentiation with other antihypertensive drugs
- Impaired absorption in the presence of anionic exchange resins
Contraindications
- Hypersensitivity to any component of the product
- Anuria
- Hypersensitivity to other sulfonamide-derived drugs
Side Effects
- Symptomatic hypotension including dizziness
- Occasional hyperkalaemia
- Reported angioedema, vertigo, gastro-intestinal disturbances, angina, palpitation, oedema, dyspnoea, headache, sleep disorders, malaise, urticaria, pruritus, rash, hepatitis, atrial fibrillation, cerebrovascular accident, syncope, paraesthesia, pancreatitis, anaphylaxis, cough, depression, erectile dysfunction, anaemia, thrombocytopenia, hyponatraemia, arthralgia, myalgia, renal impairment, rhabdomyolysis, tinnitus, photosensitivity, and vasculitis
Pregnancy & Lactation
- Avoid in pregnancy unless essential
- May adversely affect fetal and neonatal blood pressure control and renal function
- Not recommended in breastfeeding
Precautions & Warnings
- Angiooedema hypersensitivity
- Periodic determination of serum electrolytes
- Rare development of hypokalemia
- Impaired renal function
- Symptomatic hypotension
Use in Special Populations
- Use in Patients with Renal Impairment
- Use in Patients with Hepatic Impairment
- Safety and effectiveness not established in pediatric patients
Overdose Effects
- Likely manifestations of hypotension and tachycardia
- Supportive treatment for symptomatic hypotension
- Limited data available for overdosage
- Common signs and symptoms caused by electrolyte depletion
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Do not store above 30°C
- Keep out of the reach of children
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