CardoPlus 50 mg+12.5 mg (Tablet)

Unit Price: ৳ 10.00 (4 x 10: ৳ 400.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Eskayef pharmaceuticals ltd

Indications

  • Treatment of hypertension
  • Reducing risk of stroke in patients with hypertension and left ventricular hypertrophy

Pharmacology

  • Potent vasoconstrictor
  • Affects renin-angiotensin system
  • Stimulates aldosterone secretion
  • Blocker of angiotensin II binding

Dosage

  • Usual starting dose of 50/12.5 is one tablet once daily
  • Maximum dose is 100/25 once daily
  • Antihypertensive effect attained within three weeks after initiation

Administration

  • May be administered with other antihypertensive agents
  • Can be taken with or without food

Interaction

  • No significant drug-drug interactions with Losartan Potassium
  • Potential interactions with thiazide diuretics and antidiabetic drugs
  • Additive effect with other antihypertensive drugs

Contraindications

  • Hypersensitivity to any component of the product
  • Contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs

Side Effects

  • Symptomatic hypotension including dizziness
  • Occasional hyperkalaemia
  • Vertigo
  • Gastro-intestinal disturbances
  • Angioedema
  • Headache
  • Urticaria
  • Pruritus

Pregnancy & Lactation

  • Avoided in pregnancy unless essential
  • Not recommended in breastfeeding

Precautions & Warnings

  • Periodic determination of serum electrolytes
  • Hypokalemia may rarely develop
  • Impaired renal function should be monitored
  • Symptomatic hypotension should be considered

Use in Special Populations

  • Usual regimens may be followed in patients with creatinine clearance >30 ml/min
  • Loop diuretics preferred in severe renal impairment
  • Not recommended in patients with hepatic impairment
  • Safety and effectiveness not established in pediatric patients

Overdose Effects

  • Likely manifestations include hypotension, tachycardia, and bradycardia
  • Supportive treatment should be instituted if symptomatic hypotension occurs
  • Most common signs and symptoms involve electrolyte depletion

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Do not store above 30°C
  • Keep out of the reach of children

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