Pantogen 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.03 (5 x 10: ৳ 351.50)

Strip Price: ৳ 70.30

Medicine Details

Category	Details
Generic	Pantoprazole sodium
Company	General pharmaceuticals ltd
Also available as	Pantogen 20 mg tablet

Indications

Peptic ulcer diseases
Gastroesophageal reflux diseases
Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
Eradication of Helicobacter pylori (in combination with antibiotics)
Zollinger-Ellison Syndrome

Pharmacology

Proton pump inhibitor
Suppression of the final step in gastric acid production
Covalently binds to H+/K+ATPase enzyme system
Inhibition of both basal and stimulated gastric acid secretion
Effect persists longer than 24 hours

Dosage & Administration

40 mg daily in the morning for benign gastric ulcer for 4 weeks, continued for further 4 weeks if not fully healed
20-40 mg daily in the morning for gastro-esophageal reflux disease for 4 weeks, continued for further 4 weeks if not fully healed
40 mg daily in the morning for duodenal ulcer for 2 weeks, continued for further 2 weeks if not fully healed
Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents for duodenal ulcer associated with Helicobacter pylori
20 mg daily for prophylaxis of NSAID-associated gastric or duodenal ulcer
Initially 80 mg once daily for Zollinger-Ellison Syndrome, adjusted according to response; daily doses above 80 mg given in 2 divided doses
40 mg IV once daily for duodenal ulcer and gastric ulcer for 7-10 days
40 mg IV once daily for gastroesophageal reflux disease associated with a history of erosive esophagitis for 7-10 days
IV 80 mg for prevention of rebleeding in peptic ulcer, followed by 8 mg/hour infusion for 72 hours
80 mg IV for prophylaxis of acid aspiration every 12 hours for 24 hours, followed by 40mg every 12 hours
80 mg IV every 12 hours for long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions

Interaction

No significant drug interactions observed in clinical studies

Contraindications

Contraindicated in patients with known hypersensitivity to any of the components of the formulation

Side Effects

Well tolerated in both short-term and long-term treatment
Common side effects: headache, diarrhea
Rarely included side effects: abdominal pain, flatulence, rash, insomnia, hyperglycemia

Pregnancy & Lactation

US FDA Pregnancy Category B
No adequate and well-controlled studies in pregnant women
Excretion in human milk
Use during pregnancy only if clearly needed
Decision should be made whether to discontinue nursing or drug, taking into account the benefit of the drug to the mother

Precautions & Warnings

Pantogen tablet should not be split, chewed or crushed
Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12)
May increase the risk of osteoporosis related disorders

Overdose Effects

No known symptoms of overdosage in humans
Highly protein bound, not readily dialyzable
Apart from symptomatic and supportive management, no specific therapy recommended

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

IV injection: Intravenous administration only, reconstituted with 0.9% Sodium Chloride Injection and given slowly over a period of at least 2 to 5 minutes
IV infusion: Intravenous infusion over a period of approximately 15 minutes, reconstituted with 10 ml of 0.9% Sodium Chloride Injection and further diluted with 0.9% Sodium Chloride Injection or 5% Dextrose or Lactated Ringer's Injection to a final volume of 100 ml
Reconstituted solution may be stored at room temperature for a maximum of 4 hours before further dilution, and admixed solution may be stored at room temperature and must be used within 24 hours from the time of initial reconstitution

Storage Conditions

Keep in a dry place, away from light and heat, keep out of the reach of children

Chemical Structure

Molecular Formula: C16H15F2N3O4S
Chemical Structure: Pantoprazole Sodium

Common Questions about Pantogen 40 mg Tablet

Suppression of the final step in gastric acid production
Used to treat Peptic ulcer diseases, GERD, Ulcer induced by NSAIDs, Eradication of Helicobacter pylori, Zollinger-Ellison Syndrome
Duration of use dependent on improvement in health conditions
Frequency and timing of dosage as prescribed by the doctor
Instructions for storage and disposal
Increased risk for bone fractures in older adults with longer use and higher doses
Onset of improvement within 2 to 3 days, full effectiveness in up to 4 weeks
Relatively safe, advised to consult the doctor before consumption
Rare cases of weight gain, consultation advised
Side effects include headache, diarrhea, constipation, and allergic reaction
Consideration advised before use during pregnancy or breastfeeding
Instructions for missed dose