Devoid 25 mg+50 mg (Tablet)
Unit Price: ৳ 3.00 (5 x 10: ৳ 150.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Meclizine pyridoxine |
| Company | Benham pharmaceuticals ltd |
Indications
- Prevention and treatment of nausea
- Prevention and treatment of vomiting
- Prevention and treatment of dizziness
- Prevention and treatment of motion sickness
- Prevention and treatment of radiation sickness
- Prevention and treatment of vertigo
- Associated with diseases of the vestibular system (e.g. Meniere's syndrome, labyrinthitis and other vestibular disturbances)
Pharmacology
- Piperazine-derivative antihistamine
- Antiemetic
- Anticholinergic properties
- Antihistaminic properties
- Reduces sensitivity of the labyrinthine apparatus
- Action mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ)
- Pyridoxine is vitamin B-6 added to enhance the anti-emetic effects & as a dietary supplement
Dosage & Administration
- Adult and Children 12 years of age & over
- Nausea and vomiting: 25-50 mg daily or as directed by a physician
- Motion sickness: Initial dose of 25-50 mg, 1 hour prior to travel. May repeat the dose every 24 hours for the duration of the journey
- Radiation sickness: 50 mg administered 2-12 hours prior to radiation treatment
- Vertigo: 25-100 mg daily in divided doses
- Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP): 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours
- Safety and efficacy for use in children less than 12 years of age have not been established
Interaction
- Potentiation of CNS depressant effects by Ethanol or other CNS depressant agents such as Benzodiazepines, Barbiturates, Tricyclic antidepressants, opiate agonists, skeletal muscle relaxants and antihistamines
- Concurrent use of other anticholinergics can potentiate the anticholinergic effects
- Increased absorption of digoxin by decreasing gastrointestinal motility
Contraindications
- Hypersensitivity to Meclizine Hydrochloride
- Hypersensitivity to Pyridoxine Hydrochloride
Side Effects
- Drowsiness
- Dry mouth
- Blurred vision (rare)
Pregnancy & Lactation
- Pregnancy Category B
- No demonstrated adverse fetal effects in large-scale human studies
- Lowest risk of teratogenicity
- Drug of first choice in treating nausea and vomiting during pregnancy
- Safety for use in the nursing mother has not been established
Precautions & Warnings
- Impairment of ability to perform hazardous activities requiring mental alertness or physical coordination
- Avoidance of alcoholic beverages while taking the product
- Caution in patients with asthma, glaucoma or enlargement of the prostate gland
Overdose Effects
- Symptoms: Extreme excitability, seizures, drowsiness, hallucinations
- Treatment: Appropriate supportive and symptomatic treatment. Consider dialysis
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children