Menem 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 700.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Astra biopharmaceuticals ltd
Also available as
Menem 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action interfering with bacterial cell wall synthesis

Dosage

  • Adults:
    • 500 mg to 1 gm by intravenous administration every 8 hours
    • Varied dosage for different infections
  • Children:
    • 10 to 40 mg/kg intravenously every 8 hours
    • Varied dosage for different types of infections

Administration

Intravenous infusion over 15-30 minutes or as intravenous bolus over 3-5 minutes

Interaction

  • Probenecid: Competes with Menem for active tubular secretion
  • Valproic acid: May reduce serum levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B. Caution during breastfeeding

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Use in patients with hepatic disease with careful monitoring of transaminase and bilirubin levels

Use in Special Populations

  • Renal impairment: Dosage reduction for creatinine clearance <51 ml/min
  • Hepatic impairment: No dosage adjustments needed
  • Elderly: No dosage adjustments needed
  • Children: Efficacy and tolerability in infants under 3 months not established

Overdose Effects

Symptomatic treatment, haemodialysis for renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitute with sterile water for injection
  • Intravenous infusion administration: May be directly constituted with compatible infusion fluid
  • Compatibility with infusion fluids:
    • 0.9% sodium chloride
    • 5% or 10% glucose
    • 5% glucose with 0.02% sodium bicarbonate
    • 5% glucose and 0.9% sodium chloride
    • 5% glucose with 0.225% sodium chloride
    • 5% glucose with 0.15% potassium chloride
    • 2.5% and 10% mannitol
    • normosol-M in 5% glucose

Storage Conditions

Store below 30°C, away from light & moisture

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