Merolab 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,365.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Labaid pharma ltd
Also available as
Merolab 500 mg injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Interferes with bacterial cell wall synthesis, penetrates bacterial cell walls, stable to serine beta-lactamases, affinity for Penicillin Binding Proteins, active against Gram-positive and Gram-negative bacteria

Dosage

  • Adults: 500 mg to 1 gm by intravenous administration every 8 hours
  • Children: 10 to 40 mg/kg intravenously every 8 hours
  • Intra-abdominal infections: 20 mg/kg every 8 hours
  • Cystic fibrosis (4-18 years): 25-40 mg/kg every 8 hours
  • Meningitis: 40 mg/kg IV every 8 hours
  • Febrile neutropenia: 20 mg/kg every 8 hours
  • Children over 50 kg weight: use adult dosage

Administration

Intravenous infusion over approximately 15-30 minutes or as intravenous bolus (5 to 20 ml) over approximately 3-5 minutes

Interaction

  • Probenecid competes with Merolab for active tubular secretion
  • May reduce serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B. Caution recommended during nursing

Precautions & Warnings

Discontinue if allergic reaction occurs, careful monitoring in hepatic disease

Use in Special Populations

  • Dosage reduction in renal impairment
  • No dosage adjustments in hepatic impairment
  • Caution in infants under 3 months

Overdose Effects

Symptomatic treatment for accidental overdose, hemodialysis for renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitute with sterile water for injection
  • Intravenous infusion administration: may be directly constituted with compatible infusion fluid and further diluted

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture

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