Merolab 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 790.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Labaid pharma ltd
Also available as
Merolab 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis, potent activity against a broad spectrum of bacteria.

Dosage

  • Adults: 500 mg to 1 gm intravenous every 8 hours
  • Children: 10 to 40 mg/kg intravenous every 8 hours, dosage varies with infection type and severity

Administration

  • Intravenous Infusion over 15-30 minutes
  • Intravenous bolus over 3-5 minutes

Interaction

Probenecid competes with Merolab for active tubular secretion, may reduce serum valproic acid levels

Contraindications

Hypersensitivity to Meropenem

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B, caution during nursing

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Use in patients with hepatic disease requires careful monitoring

Use in Special Populations

  • Renal Impairment: Dosage reduction for creatinine clearance < 51 ml/min
  • Hepatic Impairment: No dosage adjustment needed, hemodialysis patients should receive post-dialysis
  • Elderly: No dosage adjustments unless creatinine clearance < 51 ml/min
  • Children: Efficacy and tolerability not established in infants under 3 months

Overdose Effects

Symptomatic treatment, haemodialysis for renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous Bolus Administration: Reconstitute with sterile water for injection
  • Intravenous Infusion Administration: May be constituted directly with compatible infusion fluids and further diluted

Compatible Infusion Fluids

  • 0.9% sodium chloride
  • 5% or 10% glucose
  • 5% glucose with 0.02% sodium bicarbonate
  • 5% glucose and 0.9% sodium chloride
  • 5% glucose with 0.225% sodium chloride
  • 5% glucose with 0.15% potassium chloride
  • 2.5% and 10% mannitol
  • normosol-M in 5% glucose

Solution Potency

Maintains potency for up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

Store in a cool, dry place below 30°C, away from light and moisture

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