Neopenem 250 mg/vial (IV Injection or Infusion)

250 mg vial: ৳ 450.00

Medicine Details

Category	Details
Generic	Meropenem trihydrate
Company	Healthcare pharmaceuticals ltd
Also available as	Neopenem 500 mg injection Neopenem 1 gm injection

Indications

Pneumonia and Nosocomial Pneumonia
Urinary Tract Infections
Intra-abdominal Infections
Gynaecological Infections
Skin and Skin Structure Infections
Meningitis
Septicaemia
Pulmonary infections in cystic fibrosis
Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis, penetrates bacterial cell walls, stability to all serine beta-lactamases, affinity for Penicillin Binding Proteins, potent bactericidal activity against a broad spectrum of bacteria

Dosage

Adults:
- 500 mg to 1 gm by intravenous administration every 8 hours
- Different dosages for specific infections
Children:
- 10 to 40 mg/kg intravenously every 8 hours
- Different dosages for specific infections

Administration

Intravenous Infusion over approximately 15-30 minutes
Intravenous bolus over approximately 3-5 minutes

Interaction

Competes with Neopenem for active tubular secretion
Reduces serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

Inflammation
Thrombophlebitis
Pain at the site of injection
Skin reactions
Abdominal pain
Nausea
Vomiting
Diarrhea
Headache

Pregnancy & Lactation

Pregnancy Category B, caution during nursing

Precautions & Warnings

Allergic reaction precautions
Monitoring of hepatic disease patients

Use in Special Populations

Dosage adjustments for renal impairment
No adjustments with liver function impairment
Hemodialysis patients precautions
Elderly precautions
No established efficacy and tolerability in infants under 3 months

Overdose Effects

Symptomatic treatment, removal by haemodialysis in subjects with renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

Intravenous bolus Administration: Reconstitute with sterile water for injection, clear and colorless or pale yellow solution
Intravenous infusion administration: Compatible with various infusion fluids, maintains potency for up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture, keep out of reach of children