Penomer 1 gm/vial (IV Injection or Infusion)
Medicine Details
Category | Details |
---|---|
Generic | Meropenem trihydrate |
Company | Beximco pharmaceuticals ltd |
Also available as |
Indications
- Pneumonia and Nosocomial Pneumonia
- Urinary Tract Infections
- Intra-abdominal Infections
- Gynaecological Infections
- Skin and Skin Structure Infections
- Meningitis
- Septicaemia
- Pulmonary infections in cystic fibrosis
- Empiric treatment for presumed infections in patients with febrile neutropenia
Pharmacology
Bactericidal action by interfering with bacterial cell wall synthesis, potent against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria
Dosage
- Adults:
- 500 mg to 1 gm by intravenous administration every 8 hours
- Different dosages for specific infections
- Children:
- 10 to 40 mg/kg intravenously every 8 hours
- Different dosages for specific infections
Administration
Intravenous infusion over approximately 15-30 minutes or intravenous bolus over approximately 3-5 minutes
Interaction
Competes with Penomer for active tubular secretion, may reduce serum valproic acid levels
Contraindications
Hypersensitivity to the product
Side Effects
- Inflammation
- Thrombophlebitis
- Pain at the site of injection
- Skin reactions like rash, pruritus, urticaria
- Abdominal pain
- Nausea
- Vomiting
- Diarrhea
- Headache
Pregnancy & Lactation
Pregnancy Category B, caution during lactation
Precautions & Warnings
- Discontinue if allergic reaction occurs
- Use with careful monitoring in hepatic disease patients
Use in Special Populations
- Dosage adjustments for renal impairment
- No dosage adjustments necessary for hepatic impairment
- No dosage adjustments for elderly unless creatinine clearance is <51 ml/min
- Efficacy and tolerability not established in infants under 3 months
Overdose Effects
Symptomatic treatment, rapid renal elimination in normal individuals, haemodialysis for subjects with renal impairment
Therapeutic Class
Other beta-lactam Antibiotics
Reconstitution
- Intravenous bolus Administration: Reconstitute with sterile water for injection
- Intravenous infusion administration: May be directly constituted with compatible infusion fluid and then further diluted
Compatible Infusion Fluids
- 0.9% sodium chloride intravenous infusion
- 5% or 10% glucose intravenous infusion
- 5% glucose intravenous infusion with 0.02% sodium bicarbonate
- 5% glucose and 0.9% sodium chloride intravenous infusion
- 5% glucose with 0.225% sodium chloride intravenous infusion
- 5% glucose with 0.15% potassium chloride intravenous infusion
- 2.5% and 10% mannitol intravenous infusion
- normosol-M in 5% glucose intravenous infusion
Reconstituted Solution Potency
Maintains potency for up to 3 hours at up to 25°C or 13 hours at up to 5°C
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture, keep out of the reach of children
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