Penomer 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,300.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Beximco pharmaceuticals ltd
Also available as
Penomer 500 mg injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis, potent against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria

Dosage

  • Adults:
    • 500 mg to 1 gm by intravenous administration every 8 hours
    • Different dosages for specific infections
  • Children:
    • 10 to 40 mg/kg intravenously every 8 hours
    • Different dosages for specific infections

Administration

Intravenous infusion over approximately 15-30 minutes or intravenous bolus over approximately 3-5 minutes

Interaction

Competes with Penomer for active tubular secretion, may reduce serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

Pregnancy Category B, caution during lactation

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Use with careful monitoring in hepatic disease patients

Use in Special Populations

  • Dosage adjustments for renal impairment
  • No dosage adjustments necessary for hepatic impairment
  • No dosage adjustments for elderly unless creatinine clearance is <51 ml/min
  • Efficacy and tolerability not established in infants under 3 months

Overdose Effects

Symptomatic treatment, rapid renal elimination in normal individuals, haemodialysis for subjects with renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitute with sterile water for injection
  • Intravenous infusion administration: May be directly constituted with compatible infusion fluid and then further diluted

Compatible Infusion Fluids

  • 0.9% sodium chloride intravenous infusion
  • 5% or 10% glucose intravenous infusion
  • 5% glucose intravenous infusion with 0.02% sodium bicarbonate
  • 5% glucose and 0.9% sodium chloride intravenous infusion
  • 5% glucose with 0.225% sodium chloride intravenous infusion
  • 5% glucose with 0.15% potassium chloride intravenous infusion
  • 2.5% and 10% mannitol intravenous infusion
  • normosol-M in 5% glucose intravenous infusion

Reconstituted Solution Potency

Maintains potency for up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture, keep out of the reach of children

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