Penomer 500 mg/vial (IV Injection or Infusion)
500 mg vial: ৳ 700.00
Medicine Details
Category | Details |
---|---|
Generic | Meropenem trihydrate |
Company | Beximco pharmaceuticals ltd |
Also available as |
Indications
- Pneumonia and Nosocomial Pneumonia
- Urinary Tract Infections
- Intra-abdominal Infections
- Gynaecological Infections
- Skin and Skin Structure Infections
- Meningitis
- Septicaemia
- Pulmonary infections in cystic fibrosis
- Empiric treatment for presumed infections in patients with febrile neutropenia
Pharmacology
Exerts bactericidal action by interfering with bacterial cell wall synthesis. Potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria.
Dosage
- Adults: Usual dose is 500 mg to 1 gm intravenously every 8 hours. Dosage varies based on infection type and severity.
- Children: Dosage varies from 10 to 40 mg/kg intravenously every 8 hours depending on infection type and severity.
Administration
- Intravenous Infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes.
Interaction
- Competes with Penomer for active tubular secretion and may reduce serum valproic acid levels.
Contraindications
Contraindicated in patients who have demonstrated hypersensitivity to this product.
Side Effects
- Inflammation at the site of injection
- Thrombophlebitis
- Skin reactions like rash, pruritus, urticaria
- Abdominal pain, nausea, vomiting, diarrhea
- Headache
Pregnancy & Lactation
- Pregnancy Category B. Use during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman.
Precautions & Warnings
- Discontinue if an allergic reaction occurs
- Monitor transaminase and bilirubin levels in patients with hepatic disease
Use in Special Populations
- Dosage should be reduced in patients with creatinine clearance less than 51 ml/min
- No dosage adjustments necessary for patients with impairment of liver function
- No dosage adjustments necessary in elderly patients unless creatinine clearance is <51 ml/min
- Efficacy and tolerability in infants under 3 months have not been established
Overdose Effects
Accidental overdose could occur during therapy, particularly in patients with renal impairment. Treatment should be symptomatic.
Therapeutic Class
- Carbapenem Antibiotic
Reconstitution
Intravenous bolus reconstitution: Use sterile water for injection and shake to dissolve. Intravenous infusion reconstitution: May be directly constituted with compatible infusion fluids and further diluted as needed.
Storage Conditions
Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.
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