Penomer 500 mg/vial (IV Injection or Infusion)

500 mg vial: ৳ 700.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Beximco pharmaceuticals ltd
Also available as
Penomer 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Exerts bactericidal action by interfering with bacterial cell wall synthesis. Potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria.

Dosage

  • Adults: Usual dose is 500 mg to 1 gm intravenously every 8 hours. Dosage varies based on infection type and severity.
  • Children: Dosage varies from 10 to 40 mg/kg intravenously every 8 hours depending on infection type and severity.

Administration

  • Intravenous Infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes.

Interaction

  • Competes with Penomer for active tubular secretion and may reduce serum valproic acid levels.

Contraindications

Contraindicated in patients who have demonstrated hypersensitivity to this product.

Side Effects

  • Inflammation at the site of injection
  • Thrombophlebitis
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain, nausea, vomiting, diarrhea
  • Headache

Pregnancy & Lactation

  • Pregnancy Category B. Use during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman.

Precautions & Warnings

  • Discontinue if an allergic reaction occurs
  • Monitor transaminase and bilirubin levels in patients with hepatic disease

Use in Special Populations

  • Dosage should be reduced in patients with creatinine clearance less than 51 ml/min
  • No dosage adjustments necessary for patients with impairment of liver function
  • No dosage adjustments necessary in elderly patients unless creatinine clearance is <51 ml/min
  • Efficacy and tolerability in infants under 3 months have not been established

Overdose Effects

Accidental overdose could occur during therapy, particularly in patients with renal impairment. Treatment should be symptomatic.

Therapeutic Class

  • Carbapenem Antibiotic

Reconstitution

Intravenous bolus reconstitution: Use sterile water for injection and shake to dissolve. Intravenous infusion reconstitution: May be directly constituted with compatible infusion fluids and further diluted as needed.

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.

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