Specbac 250 mg/vial (IV Injection or Infusion)

250 mg vial: ৳ 400.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Square pharmaceuticals plc
Also available as
Specbac 500 mg injection Specbac 1 gm injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis, potent activity against a broad spectrum of bacteria

Dosage

  • Adults:
    • 500 mg - 1 gm every 8 hours for different infections
  • Children:
    • 10 - 40 mg/kg every 8 hours for different infections

Administration

Intravenous infusion over 15-30 minutes or as intravenous bolus over 3-5 minutes

Interaction

  • Competes with Specbac for active tubular secretion
  • Reduces serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at injection site
  • Skin reactions
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

  • Pregnancy Category B
  • Caution in nursing women

Precautions & Warnings

  • Discontinue if allergic reaction occurs
  • Monitor transaminase and bilirubin levels in hepatic disease patients

Use in Special Populations

  • Renal Impairment: Dosage reduction for creatinine clearance <51 ml/min
  • Hepatic Impairment: No dosage adjustments needed
  • Elderly: No dosage adjustments needed unless creatinine clearance <51 ml/min
  • Children: Efficacy and tolerability not established in infants under 3 months

Overdose Effects

Symptomatic treatment for accidental overdose, haemodialysis for renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

  • Intravenous bolus Administration: Reconstitute with sterile water for injection
  • Intravenous infusion administration: Constitute with compatible infusion fluid and further dilute
  • Compatible Infusion Fluids:
    • 0.9% sodium chloride
    • 5% or 10% glucose
    • 5% glucose with 0.02% sodium bicarbonate
    • 5% glucose and 0.9% sodium chloride
    • 5% glucose with 0.225% sodium chloride
    • 5% glucose with 0.15% potassium chloride
    • 2.5% and 10% mannitol
    • normosol-M in 5% glucose
  • Potency: Maintains potency for up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

Store in a cool, dry place below 30°C, away from light & moisture

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