M-Fort 500 mg (Tablet)

Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Albion laboratories limited
Also available as
M fort 850 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus in adults
  • Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
  • Reduction of diabetic complications in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure

Pharmacology

  • Metformin is a biguanide type oral antihyperglycemic drug
  • Lowers both basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity by an increase in peripheral glucose uptake and utilization

Dosage & Administration

  • Usual starting dose of Metformin for adults
  • Usual starting dose of Metformin for children
  • Maximum daily dose for adults
  • Maximum daily dose for children
  • Instructions for taking Metformin extended release tablet
  • Usage in renal impaired patients

Interaction

  • No information available about the interaction of M-Fort and Furosemide when co-administered chronically
  • Effect of Nifedipine on the absorption of M-Fort
  • Potential interaction of M-Fort with cationic drugs eliminated by renal tubular secretion
  • Effect of M-Fort on Cimetidine pharmacokinetics
  • Drugs that tend to produce hyperglycemia and may lead to loss of glycemic control

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Acute metabolic acidosis contraindication
  • Severe renal failure contraindication
  • Acute conditions with the potential to alter renal function contraindication
  • Acute or chronic diseases contraindication

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities or hepatitis
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes during pregnancy associated risk
  • Recommendation to use insulin during pregnancy
  • Excretion of Metformin into human breast milk
  • Limited data available on breastfeeding during metformin treatment

Precautions & Warnings

  • Risk of M-Fort accumulation and lactic acidosis in patients with impaired renal function
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia when used in combination with insulin or insulin secretagogue
  • Regular monitoring of renal function
  • Temporary discontinuation of M-Fort in specific clinical investigations and conditions
  • Annual estimation of Vitamin B-12 levels
  • Interaction with cimetidine and anticoagulants

Use in Special Populations

  • Adjusted metformin dosage for elderly subjects
  • No effect of metformin on growth and puberty detected in controlled clinical studies
  • Recommended cautious prescribing to children aged between 10 and 12 years
  • Assessment of renal function before and regularly after initiation of treatment
  • Special caution in situations where renal function may become impaired

Overdose Effects

  • Hypoglycemia not seen with M-Fort doses up to 85 grams
  • Lactic acidosis occurrence in overdose circumstances
  • Emergency treatment of lactic acidosis in hospital
  • Hemodialysis as the most effective method to remove lactate and M-Fort

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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