M-Fort 500 mg (Tablet)
Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Albion laboratories limited |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure
Pharmacology
- Metformin is a biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity by an increase in peripheral glucose uptake and utilization
Dosage & Administration
- Usual starting dose of Metformin for adults
- Usual starting dose of Metformin for children
- Maximum daily dose for adults
- Maximum daily dose for children
- Instructions for taking Metformin extended release tablet
- Usage in renal impaired patients
Interaction
- No information available about the interaction of M-Fort and Furosemide when co-administered chronically
- Effect of Nifedipine on the absorption of M-Fort
- Potential interaction of M-Fort with cationic drugs eliminated by renal tubular secretion
- Effect of M-Fort on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia and may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Acute metabolic acidosis contraindication
- Severe renal failure contraindication
- Acute conditions with the potential to alter renal function contraindication
- Acute or chronic diseases contraindication
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated risk
- Recommendation to use insulin during pregnancy
- Excretion of Metformin into human breast milk
- Limited data available on breastfeeding during metformin treatment
Precautions & Warnings
- Risk of M-Fort accumulation and lactic acidosis in patients with impaired renal function
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia when used in combination with insulin or insulin secretagogue
- Regular monitoring of renal function
- Temporary discontinuation of M-Fort in specific clinical investigations and conditions
- Annual estimation of Vitamin B-12 levels
- Interaction with cimetidine and anticoagulants
Use in Special Populations
- Adjusted metformin dosage for elderly subjects
- No effect of metformin on growth and puberty detected in controlled clinical studies
- Recommended cautious prescribing to children aged between 10 and 12 years
- Assessment of renal function before and regularly after initiation of treatment
- Special caution in situations where renal function may become impaired
Overdose Effects
- Hypoglycemia not seen with M-Fort doses up to 85 grams
- Lactic acidosis occurrence in overdose circumstances
- Emergency treatment of lactic acidosis in hospital
- Hemodialysis as the most effective method to remove lactate and M-Fort
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children