Metfomin 500 mg (Tablet)

Unit Price: ৳ 3.00 (3 x 10: ৳ 90.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Astra biopharmaceuticals ltd
Also available as
Metfomin 850 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus in adults
  • Treatment of type 2 diabetes mellitus in children and adolescents
  • Reduction of diabetic complications in overweight patients
  • First-line therapy after diet failure

Pharmacology

  • Oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action than sulfonylureas
  • Improves insulin sensitivity
  • Decreases hepatic glucose production

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Usual starting dose of 500 mg twice a day for adults
  • Dosage increases in increments of 500 mg or 850 mg
  • Maximum recommended daily doses
  • Dosage of Metformin XR for adults and children
  • Recommendations for renal impaired patients

Interaction

  • Possible interaction with Furosemide and Nifedipine
  • Competing for renal tubular transport systems with cationic drugs
  • Effects on Cimetidine pharmacokinetics
  • Drugs that may lead to loss of glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes risk during pregnancy
  • Recommendation to use insulin during pregnancy
  • Excretion into human breast milk
  • No adverse effects observed in breastfed newborns/infants

Precautions & Warnings

  • Excretion by the kidney
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Monitoring of renal function
  • Temporary discontinuation before surgery
  • Annual estimation of Vitamin B-12 levels
  • Stabilization with insulin in hospital
  • Interaction with cimetidine and anticoagulants

Use in Special Populations

  • Adjustment of dosage for elderly subjects
  • Diagnosis of type 2 diabetes mellitus in children
  • Effect on growth and puberty in children
  • Creatinine clearance determination before treatment
  • Regular monitoring of renal function
  • Decreased renal function in elderly subjects

Overdose Effects

  • Absence of hypoglycemia with doses up to 85 gm
  • Occurrence of lactic acidosis in such circumstances
  • Emergency treatment in hospital
  • Hemodialysis for removal of lactate and Metfomin

Therapeutic Class

  • Biguanides

Storage Conditions

  • Temperature below 30°C
  • Protection from light and moisture
  • Keep out of the reach of children

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