Metfomin 850 mg (Tablet)
Unit Price: ৳ 4.00 (4 x 7: ৳ 112.00)
Strip Price: ৳ 28.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Astra biopharmaceuticals ltd |
| Also available as |
Title
- Metformin Tablets
Categories
- Medicine
- Pharmacy
- Diabetes Management
- Antidiabetic Drugs
Description
- Metformin tablets are used for the treatment of type 2 diabetes mellitus in adults and children over 10 years of age. It helps in managing blood glucose levels and improving insulin sensitivity.
Dosage Form
- Tablet
- Extended Release Tablet
Dosage Administration
- Individualized dosage based on effectiveness and tolerance
- Dosing based on patient age (adults and children)
- Swallowing extended-release tablets whole, without crushing, cutting, or chewing
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Improves insulin sensitivity and peripheral glucose uptake
Interaction
- Potential interactions with drugs like Furosemide and Nifedipine
- Caution with cationic drugs eliminated by renal tubular secretion
- Certain drugs may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis, severe renal failure, acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
- Not advised in conditions causing dehydration or in patients with serious infections or trauma
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders like nausea, vomiting, diarrhea, abdominal pain
- Liver function test abnormalities or hepatitis
- Skin reactions like erythema, pruritus, urticaria
Pregnancy and Lactation
- Uncontrolled diabetes during pregnancy increases risk of congenital abnormalities and perinatal mortality
- Not recommended during pregnancy but insulin can be used
- Excreted into human breast milk
- Breastfeeding not recommended during treatment
Precautions and Warnings
- Substantially excreted by the kidney
- Increases risk of lactic acidosis and hypoglycemia in combination with insulin
- Regular monitoring of renal function advised
- Caution with dehydration, serious infections, trauma
- Annual estimation of Vitamin B-12 levels recommended
- Stabilization of diabetic patients with Metformin and insulin should be in hospital
Use in Special Populations
- Dosage adjustment based on renal function in elderly subjects
- Confirmation of type 2 diabetes mellitus before treatment initiation in children
- No effect on growth and puberty detected in controlled clinical studies for a year
- Renal function assessment and caution in elderly subjects
- Contraindicated in patients with GFR less than 30 mL/min
Overdose Effects
- Lactic acidosis observed in overdose situations
- Hemodialysis recommended for removal of lactate and Metfomin
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light and moisture
- Keep out of the reach of children