Benformin 850 mg (Tablet)

Unit Price: ৳ 6.50 (5 x 10: ৳ 325.00)
Strip Price: ৳ 65.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Benham pharmaceuticals ltd
Also available as
Benformin 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus in adults
  • Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
  • Reduction of diabetic complications in overweight type 2 diabetic adult patients

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers both basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Usual starting dose for adults: 500 mg twice a day or 850 mg once a day
  • Usual starting dose for children: 500 mg twice a day
  • Dosage increases should be made in increments of 500 mg or 850 mg
  • Maximum recommended daily dose for adults: 2000 mg per day
  • Maximum recommended daily dose for children: 2000 mg per day
  • Dosage for renal impaired patients
  • Usual starting dose for Metformin XR: 500 mg once daily with the evening meal
  • Maximum recommended daily dose for Metformin XR: 2000 mg once daily with the evening meal
  • Swallow Metformin XR tablet whole and never crush, cut or chew

Interaction

  • No information available about the interaction of Benformin and Furosemide when co-administered chronically
  • Nifedipine appears to enhance the absorption of Benformin
  • Benformin had minimal effects on Nifedipine
  • Possible interaction with cationic drugs eliminated by renal tubular secretion
  • Benformin has no effect on Cimetidine pharmacokinetics
  • Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Any type of acute metabolic acidosis
  • Severe renal failure
  • Acute conditions with potential to alter renal function
  • Acute or chronic diseases which may cause tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
  • Liver function test abnormalities or hepatitis
  • Skin reactions like erythema, pruritus, urticaria

Pregnancy & Lactation

  • Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
  • Breastfeeding not recommended during metformin treatment due to limited data available

Precautions & Warnings

  • Substantially excreted by the kidney
  • Increases risk of hypoglycemia when used in combination with insulin or insulin secretagogue
  • Regular monitoring of renal function advised
  • Benformin therapy should be stopped before surgery and reinstated only after control of renal function
  • Caution when prescribing to children aged between 10 and 12 years
  • Regular assessment of renal function is necessary in elderly subjects

Use in Special Populations

  • Dosage adjustment based on renal function in elderly subjects
  • No effect on growth and puberty detected during controlled clinical studies
  • Careful follow-up of the effect of metformin on growth and puberty recommended in children
  • Renal function assessment before treatment initiation and regularly thereafter

Overdose Effects

  • Hypoglycemia not seen with Benformin doses up to 85 gm
  • Lactic acidosis is a medical emergency and must be treated in hospital
  • Hemodialysis is the most effective method to remove lactate and Benformin

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

Related Brands