Formet XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Biopharma limited |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Overweight patients management
- Glycaemic control
- Monotherapy in adults
- Combination therapy in adults
- Combination therapy in children
- Reduction of diabetic complications
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Management of type 2 diabetes
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- No hypoglycemia production
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage
- Maximum recommended daily doses
- Starting dose for adults and children
- Dosage increments
- Usual starting dose of Metformin immediate release tablet
- Usual starting dose of Metformin extended release tablet
- Special dosing for renal impaired patient
Interaction
- No chronic interaction with Furosemide
- Enhanced absorption by Nifedipine
- Minimal effect on Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs producing hyperglycemia
- Loss of glycemic control drugs
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis contraindicated
- Severe renal failure contraindicated
- Acute conditions altering renal function contraindicated
- Conditions causing tissue hypoxia contraindicated
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Vitamin B12 absorption decrease
- Peripheral neuropathy risk
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Recommendation for insulin use during pregnancy
- Excretion into human breast milk
- No observed adverse effects in breastfed newborns/infants
- Breastfeeding not recommended during treatment
Precautions & Warnings
- Excretion by the kidney
- Risk of accumulation and lactic acidosis
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia in combination therapy
- Regular monitoring of renal function
- Stoppage before surgery and clinical investigations
- Not advised in dehydrated or serious infections patients
- Annual estimation of Vitamin B-12 levels
- Need for hospital stabilization with insulin therapy
Use in Special Populations
- Adjusted dosage in elderly
- Effect on growth and puberty
- Particular caution for children aged 10-12 years
- Regular renal function assessment
- Decreased renal function in elderly
- Caution in conditions altering renal function
- Contraindicated with GFR<30 ml/min
Overdose Effects
- No hypoglycemia with doses up to 85 gm
- Occurrence of lactic acidosis
- Treatment through hospitalization and hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children