Formet XR 500 mg (Tablet (Extended Release))

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Biopharma limited
Also available as
Formet 500 mg tablet Formet 850 mg tablet Formet xr 750 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Overweight patients management
  • Glycaemic control
  • Monotherapy in adults
  • Combination therapy in adults
  • Combination therapy in children
  • Reduction of diabetic complications

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Management of type 2 diabetes
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • No hypoglycemia production
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage
  • Maximum recommended daily doses
  • Starting dose for adults and children
  • Dosage increments
  • Usual starting dose of Metformin immediate release tablet
  • Usual starting dose of Metformin extended release tablet
  • Special dosing for renal impaired patient

Interaction

  • No chronic interaction with Furosemide
  • Enhanced absorption by Nifedipine
  • Minimal effect on Nifedipine
  • Potential interaction with cationic drugs
  • No effect on Cimetidine pharmacokinetics
  • Drugs producing hyperglycemia
  • Loss of glycemic control drugs

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis contraindicated
  • Severe renal failure contraindicated
  • Acute conditions altering renal function contraindicated
  • Conditions causing tissue hypoxia contraindicated

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Vitamin B12 absorption decrease
  • Peripheral neuropathy risk
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Recommendation for insulin use during pregnancy
  • Excretion into human breast milk
  • No observed adverse effects in breastfed newborns/infants
  • Breastfeeding not recommended during treatment

Precautions & Warnings

  • Excretion by the kidney
  • Risk of accumulation and lactic acidosis
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia in combination therapy
  • Regular monitoring of renal function
  • Stoppage before surgery and clinical investigations
  • Not advised in dehydrated or serious infections patients
  • Annual estimation of Vitamin B-12 levels
  • Need for hospital stabilization with insulin therapy

Use in Special Populations

  • Adjusted dosage in elderly
  • Effect on growth and puberty
  • Particular caution for children aged 10-12 years
  • Regular renal function assessment
  • Decreased renal function in elderly
  • Caution in conditions altering renal function
  • Contraindicated with GFR<30 ml/min

Overdose Effects

  • No hypoglycemia with doses up to 85 gm
  • Occurrence of lactic acidosis
  • Treatment through hospitalization and hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

Related Brands