Centomin 850 mg (Tablet)
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Centeon pharma ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of diabetes in overweight patients
- Monotherapy for type 2 diabetes in adults
- Combination therapy with insulin
- Usage in children from 10 years of age and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
- Decreases intestinal absorption of glucose
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Different dosages for adults and children
- Immediate release tablet and extended release tablet formulations
- Special dosage considerations for renal impaired patients
Interaction
- Co-administration interactions
- Enhancement of absorption by Nifedipine
- Potential interaction with cationic drugs
- Effects on Cimetidine pharmacokinetics
- Drugs that produce hyperglycemia and impact glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities with uncontrolled diabetes during pregnancy
- Recommendation for insulin use during pregnancy
- Excretion into human breast milk
- Limited data on breastfeeding during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Decreased vitamin B12 level
- Increased risk of hypoglycemia with insulin
- Monitoring of renal function
- Pre-surgery cessation and reinstatement
- Annual estimation of Vitamin B-12 levels
Use in Special Populations
- Adjusted dosage for elderly subjects
- Effect on growth and puberty in children
- Caution in prescribing to children aged between 10 and 12 years
- Renal function assessment and monitoring
Overdose Effects
- Hypoglycemia and lactic acidosis
- Treatment through hospital care and hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children