Centomin 850 mg (Tablet)

Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Centeon pharma ltd
Also available as
Centomin 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of diabetes in overweight patients
  • Monotherapy for type 2 diabetes in adults
  • Combination therapy with insulin
  • Usage in children from 10 years of age and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity
  • Decreases intestinal absorption of glucose

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Different dosages for adults and children
  • Immediate release tablet and extended release tablet formulations
  • Special dosage considerations for renal impaired patients

Interaction

  • Co-administration interactions
  • Enhancement of absorption by Nifedipine
  • Potential interaction with cationic drugs
  • Effects on Cimetidine pharmacokinetics
  • Drugs that produce hyperglycemia and impact glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Risk of congenital abnormalities with uncontrolled diabetes during pregnancy
  • Recommendation for insulin use during pregnancy
  • Excretion into human breast milk
  • Limited data on breastfeeding during metformin treatment

Precautions & Warnings

  • Substantial excretion by the kidney
  • Decreased vitamin B12 level
  • Increased risk of hypoglycemia with insulin
  • Monitoring of renal function
  • Pre-surgery cessation and reinstatement
  • Annual estimation of Vitamin B-12 levels

Use in Special Populations

  • Adjusted dosage for elderly subjects
  • Effect on growth and puberty in children
  • Caution in prescribing to children aged between 10 and 12 years
  • Renal function assessment and monitoring

Overdose Effects

  • Hypoglycemia and lactic acidosis
  • Treatment through hospital care and hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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