Polimet 850 mg (Tablet)
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Concord pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
- First-line therapy after diet failure
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Metformin immediate release tablet for adults
- Metformin immediate release tablet for children
- Metformin extended release tablet for adults
- Metformin extended release tablet for renal impaired patient
- Maximum recommended daily doses
- Instructions for swallowing extended release tablet whole
Interaction
- No information available about the interaction with Furosemide
- Nifedipine appears to enhance the absorption
- Cationic drugs competition for common renal tubular transport systems
- Effects on Cimetidine pharmacokinetics
- Drugs that produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Any type of acute metabolic acidosis
- Severe renal failure
- Acute conditions with potential to alter renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy is associated with increased risk of congenital abnormalities and perinatal mortality
- Use of insulin during pregnancy
- Excretion into human breast milk
- Breastfeeding not recommended
Precautions & Warnings
- Substantially excreted by the kidney
- Increased risk of lactic acidosis
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia when used with insulin
- Regular monitoring of renal function
- Monitoring of vitamin B-12 levels
- Caution when used with sulphonylurea
- Dose reduction during cimetidine therapy
- Possible interaction with anticoagulants
Use in Special Populations
- Adjust metformin dosage based on renal function in elderly
- No effect on growth and puberty detected in controlled clinical studies
- Regular follow-up of effect on growth and puberty in children recommended
- Caution recommended for children aged between 10 and 12 years
Overdose Effects
- No hypoglycemia seen with doses up to 85g
- Lactic acidosis occurred in such circumstances
- Lactic acidosis is a medical emergency treated with hemodialysis
Therapeutic Class
Biguanides
Storage Conditions
Keep below 30°C temperature, protected from light & moisture, Keep out of the reach of children
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