Metcure 500 mg (Tablet)

Unit Price: ৳ 3.80 (10 x 10: ৳ 380.00)
Strip Price: ৳ 38.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Desh pharmaceuticals ltd
Also available as
Metcure 850 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes in overweight patients
  • Monotherapy for adults with type 2 diabetes
  • Combination therapy with other oral antidiabetic agents for adults
  • Combination therapy with insulin for adults
  • Monotherapy for children (from 10 years) and adolescents with type 2 diabetes
  • Reduction of diabetic complications in overweight type 2 diabetic adult patients
  • Glycaemic control in overweight patients

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action compared to sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity
  • Increases peripheral glucose uptake and utilization

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Usual starting dose of 500 mg twice a day or 850 mg once a day for adults
  • Usual starting dose of 500 mg twice a day for children
  • Dosage increases should be made in increments of 500 mg weekly
  • Usual starting dose of 500 mg once daily with the evening meal for extended release tablet in adults
  • Dose increases in increments of 500 mg weekly for extended release tablet

Interaction

  • Absorption enhancement with Nifedipine
  • Minimal effects on Nifedipine
  • Potential interaction with cationic drugs eliminated by renal tubular secretion
  • No effect on Cimetidine pharmacokinetics
  • Certain drugs tend to produce hyperglycemia

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions affecting renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders such as nausea, vomiting, diarrhea
  • Liver function test abnormalities or hepatitis
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
  • Use of insulin recommended during pregnancy
  • Excretion into human breast milk
  • No adverse effects observed in breastfed newborns/infants
  • Breastfeeding not recommended during treatment

Precautions & Warnings

  • Excretion by the kidney
  • Risk of lactic acidosis increases with renal impairment
  • Lower vitamin B12 level
  • Increased risk of hypoglycemia when used in combination with insulin
  • Regular monitoring of renal function advised
  • Discontinuation before surgery and certain clinical investigations
  • Not advised in conditions causing dehydration or in patients suffering from serious infections or trauma

Use in Special Populations

  • Dosage adjustment in elderly subjects based on renal function
  • No effect on growth and puberty detected in controlled clinical studies
  • Particular caution recommended for children aged between 10 and 12 years
  • Renal function assessment before treatment initiation and regular monitoring

Overdose Effects

  • No hypoglycemia seen with doses up to 85 gm
  • Lactic acidosis occurred in overdose circumstances
  • Hemodialysis as the most effective method to remove lactate and Metcure

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light and moisture
  • Keep out of the reach of children

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