Metcure 850 mg (Tablet)
Unit Price: ৳ 5.50 (5 x 10: ৳ 275.00)
Strip Price: ৳ 55.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Desh pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Monotherapy for type 2 diabetes mellitus in adults
- Combination therapy for type 2 diabetes mellitus in adults
- Combination therapy for type 2 diabetes mellitus in children and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
Pharmacology
- Type of oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Mechanism of action different from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Dosage must be individualized for effectiveness and tolerance
- Maximum recommended daily doses
- Different dosages for immediate release and extended release tablets
- Dosage adjustments based on age and renal function
- Instructions for swallowing extended release tablet whole
Interaction
- Potential interactions with Furosemide and Nifedipine
- Effect on cationic drugs eliminated by renal tubular secretion
- No effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia and impact glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Use of insulin recommended during pregnancy
- Excretion of Metformin into human breast milk
- No observed adverse effects in breastfed newborns/infants
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of Metformin accumulation and lactic acidosis with renal impairment
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia when used with insulin or insulin secretagogue
- Regular monitoring of renal function
- Stoppage before surgery and clinical investigations
Use in Special Populations
- Dosage adjustment for elderly subjects based on renal function
- Regular assessment of renal function in all diabetics
- Special caution when prescribing to children aged 10-12 years
- Estimation of creatinine clearance before treatment initiation
- Contradicted in patients with GFR<30 ml/min
Overdose Effects
- No hypoglycemia seen at high doses
- Occurrence of lactic acidosis
- Emergency treatment required
- Hemodialysis as the most effective method for removal
Therapeutic Class
- Biguanides
Storage Conditions
- Temperature below 30°C
- Protection from light and moisture
- Keep out of the reach of children