Insimet XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
- First-line therapy after diet failure
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Usual starting dose of Metformin for adults
- Usual starting dose of Metformin for children
- Usual starting dose of Metformin XR for adults
- Usual starting dose of Metformin XR for children
- Instructions for Metformin extended release tablet
- Dosage adjustments for renal impaired patients
Interaction
- Absence of chronic co-administration information with Furosemide
- Enhancement of absorption by Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Any type of acute metabolic acidosis
- Severe renal failure
- Acute conditions with potential to alter renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Recommendation to use insulin instead of metformin during pregnancy
- Excretion of metformin into human breast milk
- No adverse effects observed in breastfed newborns/infants
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia in combination with insulin
- Advice for regular monitoring of renal function
- Usage advice for surgery and clinical investigations
- Not advised in conditions causing dehydration or serious infections
- Recommendation for annual estimation of Vitamin B-12 levels
- Monitoring of blood glucose during combined therapy with a sulphonylurea
- Dose reduction during cimetidine therapy
- Potential interaction with anticoagulants
Use in Special Populations
- Adjustment of metformin dosage based on renal function in elderly subjects
- No effect on growth and puberty detected during controlled clinical studies
- Caution recommended when prescribing to children aged between 10 and 12 years
- Necessity of regular assessment of renal function
- Special caution in situations where renal function may become impaired
- Contradiction in patients with GFR<30 mL/min
Overdose Effects
- No hypoglycemia seen with Insimet XR doses up to 85 gm
- Occurrence of lactic acidosis in such circumstances
- Hemodialysis as the most effective method for removal of lactate and Insimet XR
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children