Nobesit XR 500 mg (Tablet (Extended Release))
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of overweight patients with inadequate glycaemic control
- Can be used as monotherapy or in combination with other oral antidiabetic agents or insulin
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Dosage must be individualized
- Can be used in adults and children
- Different dosage for immediate release and extended release tablet
- Not to be used in severe renal impairment
Interaction
- May interact with Furosemide and Nifedipine
- Potential interactions with various cationic drugs
- Certain drugs may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions affecting renal function
Side Effects
- Blood and lymphatic system disorders: Hemolytic anemia
- Metabolism and nutrition disorders: Lactic acidosis, decrease in vitamin B12 absorption, peripheral neuropathy
- Nervous system disorders: Taste disturbance, encephalopathy
- Gastrointestinal disorders: Nausea, vomiting, diarrhea, abdominal pain
- Hepatobiliary disorders: Isolated reports of liver function test abnormalities
- Skin and subcutaneous tissue disorders: Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
- Metformin excreted into breast milk
Precautions & Warnings
- Substantially excreted by the kidney
- May lower vitamin B12 levels
- Increases risk of hypoglycemia when used with insulin or insulin secretagogue
- Regular monitoring of renal function advised
- Caution in conditions causing dehydration or serious infections
Use in Special Populations
- Elderly: Dosage adjustment based on renal function
- Pediatric population: Diagnosis confirmation required before treatment
- Renal function: Regular monitoring and assessment
Overdose Effects
- Hypoglycemia not seen at standard doses
- Lactic acidosis is a medical emergency
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C
- Protected from light & moisture
- Keep out of the reach of children