Nobesit XR 500 mg (Tablet (Extended Release))

Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Incepta pharmaceuticals ltd
Also available as
Nobesit 500 mg tablet Nobesit 850 mg tablet Nobesit xr 1000 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of overweight patients with inadequate glycaemic control
  • Can be used as monotherapy or in combination with other oral antidiabetic agents or insulin

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Dosage must be individualized
  • Can be used in adults and children
  • Different dosage for immediate release and extended release tablet
  • Not to be used in severe renal impairment

Interaction

  • May interact with Furosemide and Nifedipine
  • Potential interactions with various cationic drugs
  • Certain drugs may lead to loss of glycemic control

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions affecting renal function

Side Effects

  • Blood and lymphatic system disorders: Hemolytic anemia
  • Metabolism and nutrition disorders: Lactic acidosis, decrease in vitamin B12 absorption, peripheral neuropathy
  • Nervous system disorders: Taste disturbance, encephalopathy
  • Gastrointestinal disorders: Nausea, vomiting, diarrhea, abdominal pain
  • Hepatobiliary disorders: Isolated reports of liver function test abnormalities
  • Skin and subcutaneous tissue disorders: Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
  • Metformin excreted into breast milk

Precautions & Warnings

  • Substantially excreted by the kidney
  • May lower vitamin B12 levels
  • Increases risk of hypoglycemia when used with insulin or insulin secretagogue
  • Regular monitoring of renal function advised
  • Caution in conditions causing dehydration or serious infections

Use in Special Populations

  • Elderly: Dosage adjustment based on renal function
  • Pediatric population: Diagnosis confirmation required before treatment
  • Renal function: Regular monitoring and assessment

Overdose Effects

  • Hypoglycemia not seen at standard doses
  • Lactic acidosis is a medical emergency

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C
  • Protected from light & moisture
  • Keep out of the reach of children

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