Nobesit XR 1000 mg (Tablet (Extended Release))

Unit Price: ৳ 9.00 (5 x 6: ৳ 270.00)
Strip Price: ৳ 54.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Incepta pharmaceuticals ltd
Also available as
Nobesit 500 mg tablet Nobesit 850 mg tablet Nobesit xr 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes in overweight patients
  • Monotherapy for adults
  • Combination therapy for adults
  • Combination therapy for children and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity
  • Decreases intestinal absorption of glucose

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Usual starting dose of 500mg twice a day for adults
  • Usual starting dose of 500mg twice a day for children
  • Increase dosage in increments
  • Maximum recommended daily doses for adults
  • Maximum recommended daily doses for children
  • Swallow extended release tablet whole

Interaction

  • No chronic interaction with Furosemide
  • Enhances absorption of Nifedipine
  • Minimal effects on Nifedipine
  • Potential interaction with cationic drugs
  • No effect on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities
  • Use insulin during pregnancy
  • Excretion into human breast milk
  • Limited data on breastfeeding

Precautions & Warnings

  • Substantially excreted by the kidney
  • Decreased vitamin B12 level
  • Increases risk of hypoglycemia
  • Lower vitamin B12 levels
  • Regular monitoring of renal function
  • Therapy cessation before certain procedures
  • Caution in conditions causing dehydration
  • Monitor blood glucose during combined therapy with sulphonylurea
  • Possible interaction with anticoagulants

Use in Special Populations

  • Adjust dosage based on renal function in elderly
  • No effect on growth and puberty detected in controlled studies
  • Careful follow-up of effects on children
  • Particular caution in prescribing to children aged between 10 and 12 years
  • Regular assessment of renal function
  • Special caution in situations where renal function may become impaired
  • Regular assessment of GFR

Overdose Effects

  • No hypoglycemia observed
  • Lactic acidosis in overdose cases
  • Medical emergency requiring hospital treatment
  • Hemodialysis for removal of lactate and drug

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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