Onmet 850 mg (Tablet)
Unit Price: ৳ 5.00 (30's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Leon pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in overweight patients
- May be used in adults as monotherapy or in combination with other oral antidiabetic agents or insulin
- Reduction of diabetic complications shown in overweight type 2 diabetic adult patients treated with metformin
- Usage in children from 10 years of age and adolescents
- Improves insulin sensitivity
- Decreases hepatic glucose production
- Improves peripheral glucose uptake
- Lowers basal and postprandial plasma glucose
- Pharmacological management of type 2 diabetes
Pharmacology
- Metformin is a biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Dosage increases made in increments
- Maximum daily doses to be considered
- Swallow extended-release tablet whole, do not cut or chew
- Different dosages for adults and children
- Caution advised in renal-impaired patients
Interaction
- Potential interactions with Furosemide, Nifedipine, and cationic drugs
- May affect absorption of other medications
- Precautions needed with certain drug classes
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
Side Effects
- Blood and lymphatic system disorders
- Metabolism and nutrition disorders
- Nervous system disorders
- Gastrointestinal disorders
- Hepatobiliary disorders
- Skin and subcutaneous tissue disorders
Pregnancy & Lactation
- Use of insulin recommended during pregnancy
- Excretion into breast milk
- Breastfeeding not recommended during treatment
Precautions & Warnings
- Excretion by the kidney
- Increased risk of lactic acidosis
- Reduced Vitamin B12 levels
- Monitoring of renal function advised
- Precautions during surgeries and clinical investigations
- Regular monitoring of Vitamin B12 levels recommended
- Caution in concomitant therapy with sulfonylurea
Use in Special Populations
- Special considerations for elderly
- No effect on growth and puberty detected in controlled studies
- Regular assessment of renal function necessary
- Caution in children aged 10-12 years
- Monitoring of creatinine clearance
- GFR assessment before treatment initiation
Overdose Effects
- Hypoglycemia not seen at specific doses
- Lactic acidosis considered a medical emergency
- Treatment with hemodialysis
Therapeutic Class
- Belongs to the class of biguanides
Storage Conditions
- Store below 30°C temperature
- Protect from light and moisture
- Keep out of reach of children