Dia M 500 mg (Tablet)

Unit Price: ৳ 1.10 (50's pack: ৳ 55.00)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Medimet pharmaceuticals ltd
Also available as
Dia m 850 mg tablet Dia m sr 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes in overweight patients
  • Monotherapy for adults
  • Combination therapy for adults
  • Combination therapy for children and adolescents
  • Reduction of diabetic complications in overweight patients

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage
  • Maximum recommended daily doses
  • Starting dose for adults and children
  • Dosage increases in increments
  • Metformin immediate release tablet
  • Metformin extended release tablet
  • Special dosage for renal impaired patients

Interaction

  • No chronic co-administration with Furosemide
  • Enhanced absorption with Nifedipine
  • Minimal effects on Nifedipine
  • Potential interaction with cationic drugs
  • No effect on Cimetidine pharmacokinetics
  • Drugs causing hyperglycemia and loss of glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia
  • Acute or chronic diseases affecting renal function

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities
  • Use insulin during pregnancy
  • Excretion into human breast milk
  • Limited data on breastfeeding

Precautions & Warnings

  • Excretion by the kidney
  • Decreased vitamin B12 level
  • Increased risk of hypoglycemia
  • Regular monitoring of renal function
  • Special caution in elderly subjects
  • Effect on growth and puberty in children
  • Assessment of creatinine clearance
  • Special caution in children aged 10-12 years
  • Discontinue therapy before surgery
  • Annual estimation of Vitamin B12 levels
  • Interaction with anticoagulants

Use in Special Populations

  • Adjusted dosage in elderly subjects
  • Effect on growth and puberty
  • Caution in children aged 10-12 years
  • Assessment of renal function
  • Regular assessment of renal function

Overdose Effects

  • No hypoglycemia with doses up to 85 gm
  • Lactic acidosis as a medical emergency
  • Treatment with hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Temperature below 30°C
  • Protected from light & moisture
  • Keep out of the reach of children

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