Dia M SR 500 mg (Tablet (Sustained Release))
Unit Price: ৳ 2.00 (50's pack: ৳ 100.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Medimet pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Monotherapy for adults
- Combination therapy for adults
- Combination therapy for children and adolescents
- Reduction of diabetic complications
- First-line therapy after diet failure
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action compared to sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Usual starting dose for adults
- Dosage increases for adults
- Usual starting dose for children
- Dosage increases for children
- Usual starting dose for Metformin extended release tablet for adults
- Dosage increases for Metformin extended release tablet for adults
- Renal impaired patient precautions
Interaction
- No information about chronic co-administration with Furosemide
- Nifedipine enhances absorption
- Minimal effects on Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes associated with increased risk
- Recommendation to use insulin during pregnancy
- Excretion into human breast milk
- Limited data on breastfeeding
Precautions & Warnings
- Substantially excreted by the kidney
- Risk of lactic acidosis
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Regular monitoring of renal function
- Caution in elderly subjects
- Effect on growth and puberty
Use in Special Populations
- Adjusted dosage for elderly individuals
- Confirmation of type 2 diabetes mellitus before treatment
- Effect on growth and puberty
- Caution for children aged 10-12 years
- Regular assessment of renal function
Overdose Effects
- Absence of hypoglycemia
- Potential occurrence of lactic acidosis
- Emergency treatment in hospital
- Hemodialysis as the most effective method
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children