Dia M SR 500 mg (Tablet (Sustained Release))

Unit Price: ৳ 2.00 (50's pack: ৳ 100.00)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Medimet pharmaceuticals ltd
Also available as
Dia m 850 mg tablet Dia m 500 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Monotherapy for adults
  • Combination therapy for adults
  • Combination therapy for children and adolescents
  • Reduction of diabetic complications
  • First-line therapy after diet failure

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action compared to sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Usual starting dose for adults
  • Dosage increases for adults
  • Usual starting dose for children
  • Dosage increases for children
  • Usual starting dose for Metformin extended release tablet for adults
  • Dosage increases for Metformin extended release tablet for adults
  • Renal impaired patient precautions

Interaction

  • No information about chronic co-administration with Furosemide
  • Nifedipine enhances absorption
  • Minimal effects on Nifedipine
  • Potential interaction with cationic drugs
  • No effect on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes associated with increased risk
  • Recommendation to use insulin during pregnancy
  • Excretion into human breast milk
  • Limited data on breastfeeding

Precautions & Warnings

  • Substantially excreted by the kidney
  • Risk of lactic acidosis
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Regular monitoring of renal function
  • Caution in elderly subjects
  • Effect on growth and puberty

Use in Special Populations

  • Adjusted dosage for elderly individuals
  • Confirmation of type 2 diabetes mellitus before treatment
  • Effect on growth and puberty
  • Caution for children aged 10-12 years
  • Regular assessment of renal function

Overdose Effects

  • Absence of hypoglycemia
  • Potential occurrence of lactic acidosis
  • Emergency treatment in hospital
  • Hemodialysis as the most effective method

Therapeutic Class

  • Biguanides

Storage Conditions

  • Below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

Related Brands