Met XR 1000 mg (Tablet (Extended Release))

Unit Price: ৳ 10.00 (5 x 6: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Opsonin pharma ltd
Also available as
Met 500 mg tablet Met 850 mg tablet Met xr 500 mg tablet Met xr 750 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Monotherapy for adults
  • Combination therapy for adults
  • Combination therapy for children and adolescents
  • Reducing diabetic complications in overweight patients

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Starting dose for adults and children
  • Maximum recommended daily doses
  • Usage in renal impaired patients

Interaction

  • Interaction with Furosemide and Nifedipine
  • Potential interaction with cationic drugs
  • Effect on Cimetidine pharmacokinetics
  • Drugs leading to hyperglycemia and loss of glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Blood and lymphatic system disorders
  • Metabolism and nutrition disorders
  • Nervous system disorders
  • Gastrointestinal disorders
  • Hepatobiliary disorders
  • Skin and subcutaneous tissue disorders

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality
  • Recommendation for insulin usage during pregnancy
  • Excretion into human breast milk
  • Limited data on breastfeeding

Precautions & Warnings

  • Excretion by the kidney
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Regular monitoring of renal function
  • Annual estimation of Vitamin B-12 levels

Use in Special Populations

  • Dosage adjustment for elderly subjects
  • Confirmation of type 2 diabetes mellitus diagnosis before treatment
  • Effects on growth and puberty in children
  • Precaution in prescribing to children aged 10-12 years

Overdose Effects

  • Hypoglycemia and lactic acidosis
  • Treatment with hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Temperature below 30°C
  • Protection from light and moisture
  • Keep out of the reach of children

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