Radimet 850 mg (Tablet)
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Radiant pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Monotherapy for adults
- Treatment for children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight patients
- First-line therapy after diet failure
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
- Decreases intestinal absorption of glucose
Dosage & Administration
- Usual starting dose for adults: 500mg or 850mg once or twice daily
- Usual starting dose for children: 500mg twice daily
- Maximum daily doses for adults: 2000mg for immediate release tablet, 2550mg for extended release tablet
- Renal impaired patient precautions
- Swallow extended release tablet whole
Interaction
- No information on Radimet and Furosemide interaction
- Nifedipine enhances absorption of Radimet
- Cationic drugs potential for interaction with Radimet
- No effect on Cimetidine pharmacokinetics
- Certain drugs tend to produce hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes risk during pregnancy
- Metformin excreted into human breast milk
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Substantially excreted by the kidney
- Vitamin B12 level lowering
- Increased risk of hypoglycemia when used with insulin
- Regular monitoring of renal function advised
- Therapy stop before surgery and clinical investigations
- Annual estimation of Vitamin B-12 levels for continuous therapy patients
- Interactions with cimetidine and anticoagulants
Use in Special Populations
- Dosage adjustment in elderly based on renal function
- Caution in prescribing to children aged between 10 and 12 years
- Regular assessment of renal function necessary
- Decreased renal function in elderly
- Renal clearance determination before initiating treatment
- GFR assessment before treatment initiation
Overdose Effects
- Hypoglycemia not seen at high doses
- Lactic acidosis medical emergency
- Treatment with hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C
- Protected from light & moisture
- Keep out of the reach of children