Minirfor 850 mg (Tablet)
Unit Price: ৳ 6.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Rephco pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Monotherapy for adults
- Combination therapy for children and adolescents
- Reduction of diabetic complications in overweight patients
Pharmacology
- Management of type 2 diabetes
- Lowering basal and postprandial plasma glucose
- Mechanism of action different from sulfonylureas
- Improves insulin sensitivity
- Decreases hepatic glucose production
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage increments for adults and children
- Extended release tablet instructions
- Special dosage considerations for renal impaired patients
Interaction
- No chronic interaction with Furosemide
- Enhanced absorption with Nifedipine
- Potential interaction with cationic drugs
- Minimal effect on Cimetidine pharmacokinetics
- Drugs causing hyperglycemia and loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decreased vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality
- Recommendation to use insulin during pregnancy
- Excretion into human breast milk
- No adverse effects observed in breastfed newborns/infants
- Breastfeeding not recommended during treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Lowered vitamin B12 levels
- Increased risk of hypoglycemia with insulin combination
- Monitoring of renal function advised
- Dose adjustments for cimetidine therapy
- Possibility of interaction with anticoagulants
Use in Special Populations
- Dosage adjustment for elderly subjects based on renal function
- No effect on growth and puberty in controlled clinical studies
- Special caution for prescribing to children aged 10-12 years
- Regular assessment of renal function
- Contraindicated in patients with GFR<30 ml/min
Overdose Effects
- No hypoglycemia seen with doses up to 85 gm
- Lactic acidosis a medical emergency
- Treatment with hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children