Minirfor 850 mg (Tablet)

Unit Price: ৳ 6.00

Medicine Details

Category	Details
Generic	Metformin hydrochloride
Company	Rephco pharmaceuticals ltd
Also available as	Minirfor 500 mg tablet

Indications

Treatment of type 2 diabetes mellitus
Monotherapy for adults
Combination therapy for children and adolescents
Reduction of diabetic complications in overweight patients

Pharmacology

Management of type 2 diabetes
Lowering basal and postprandial plasma glucose
Mechanism of action different from sulfonylureas
Improves insulin sensitivity
Decreases hepatic glucose production

Dosage & Administration

Individualized dosage based on effectiveness and tolerance
Maximum recommended daily doses
Dosage increments for adults and children
Extended release tablet instructions
Special dosage considerations for renal impaired patients

Interaction

No chronic interaction with Furosemide
Enhanced absorption with Nifedipine
Potential interaction with cationic drugs
Minimal effect on Cimetidine pharmacokinetics
Drugs causing hyperglycemia and loss of glycemic control

Contraindications

Hypersensitivity to active substance or excipients
Acute metabolic acidosis
Severe renal failure
Conditions altering renal function
Conditions causing tissue hypoxia

Side Effects

Hemolytic anemia
Lactic acidosis
Decreased vitamin B12 absorption
Peripheral neuropathy in patients with vitamin B12 deficiency
Taste disturbance
Encephalopathy
Gastrointestinal disorders
Liver function test abnormalities or hepatitis
Skin reactions

Pregnancy & Lactation

Increased risk of congenital abnormalities and perinatal mortality
Recommendation to use insulin during pregnancy
Excretion into human breast milk
No adverse effects observed in breastfed newborns/infants
Breastfeeding not recommended during treatment

Precautions & Warnings

Substantial excretion by the kidney
Lowered vitamin B12 levels
Increased risk of hypoglycemia with insulin combination
Monitoring of renal function advised
Dose adjustments for cimetidine therapy
Possibility of interaction with anticoagulants

Use in Special Populations

Dosage adjustment for elderly subjects based on renal function
No effect on growth and puberty in controlled clinical studies
Special caution for prescribing to children aged 10-12 years
Regular assessment of renal function
Contraindicated in patients with GFR<30 ml/min

Overdose Effects

No hypoglycemia seen with doses up to 85 gm
Lactic acidosis a medical emergency
Treatment with hemodialysis

Therapeutic Class

Biguanides

Storage Conditions

Keep below 30°C temperature
Protected from light & moisture
Keep out of the reach of children

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