SB-Met 500 mg (Tablet)
Unit Price: ৳ 4.00 (100's pack: ৳ 400.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Sunman birdem pharma ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
Pharmacology
- Type 2 diabetes management
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Dosage must be individualized based on effectiveness and tolerance
- Starting dose of 500 mg or 850 mg depending on formulation
- Dosage increases should be made in increments of 500 mg or 850 mg
- Maximum daily doses based on patient type and formulation
- Dosage adjustments for renal impaired patients
Interaction
- Potential interaction with Furosemide and Nifedipine
- Possible competition with cationic drugs for renal tubular transport systems
- Minimal effect on Cimetidine pharmacokinetics
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure (GFR <30 mL/min)
- Acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders like nausea, vomiting, diarrhea, abdominal pain
- Liver function test abnormalities
- Skin reactions like erythema, pruritus, urticaria
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
- Metformin excreted into human breast milk
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of SB-Met accumulation and lactic acidosis with impaired renal function
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia when used with insulin
- Regular monitoring of renal function advised
- Discontinuation before surgery and clinical investigations
- Not advised in conditions causing dehydration or in patients with serious infections or trauma
Use in Special Populations
- Elderly: Adjustment of metformin dosage based on renal function
- Pediatric population: Diagnosis of type 2 diabetes mellitus should be confirmed before treatment with metformin is initiated
- Renal function assessment before and during treatment
Overdose Effects
- No hypoglycemia seen with SB-Met doses up to 85 gm
- Lactic acidosis occurred in such circumstances
- Hemodialysis as the most effective method to remove lactate and SB-Met
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of reach of children