SB-Met 500 mg (Tablet)

Unit Price: ৳ 4.00 (100's pack: ৳ 400.00)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Sunman birdem pharma ltd
Also available as
Sb met 850 mg tablet Sb met xr 500 mg tablet Sb met xr 1000 mg tablet Sb met 1000 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus in adults
  • Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
  • Reduction of diabetic complications in overweight type 2 diabetic adult patients

Pharmacology

  • Type 2 diabetes management
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Dosage must be individualized based on effectiveness and tolerance
  • Starting dose of 500 mg or 850 mg depending on formulation
  • Dosage increases should be made in increments of 500 mg or 850 mg
  • Maximum daily doses based on patient type and formulation
  • Dosage adjustments for renal impaired patients

Interaction

  • Potential interaction with Furosemide and Nifedipine
  • Possible competition with cationic drugs for renal tubular transport systems
  • Minimal effect on Cimetidine pharmacokinetics

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure (GFR <30 mL/min)
  • Acute conditions altering renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders like nausea, vomiting, diarrhea, abdominal pain
  • Liver function test abnormalities
  • Skin reactions like erythema, pruritus, urticaria

Pregnancy & Lactation

  • Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
  • Metformin excreted into human breast milk
  • Breastfeeding not recommended during metformin treatment

Precautions & Warnings

  • Substantial excretion by the kidney
  • Risk of SB-Met accumulation and lactic acidosis with impaired renal function
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia when used with insulin
  • Regular monitoring of renal function advised
  • Discontinuation before surgery and clinical investigations
  • Not advised in conditions causing dehydration or in patients with serious infections or trauma

Use in Special Populations

  • Elderly: Adjustment of metformin dosage based on renal function
  • Pediatric population: Diagnosis of type 2 diabetes mellitus should be confirmed before treatment with metformin is initiated
  • Renal function assessment before and during treatment

Overdose Effects

  • No hypoglycemia seen with SB-Met doses up to 85 gm
  • Lactic acidosis occurred in such circumstances
  • Hemodialysis as the most effective method to remove lactate and SB-Met

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of reach of children

Related Brands