SB-Met XR 500 mg (Tablet (Extended Release))

Unit Price: ৳ 6.00 (50's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Sunman birdem pharma ltd
Also available as
Sb met 500 mg tablet Sb met 850 mg tablet Sb met xr 1000 mg tablet Sb met 1000 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of diabetes in overweight patients
  • Reducing diabetic complications
  • Monotherapy for adults
  • Combination therapy for adults
  • Combination therapy for children and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Starting dose for adults
  • Starting dose for children
  • Maximum recommended daily doses
  • Instructions for immediate release tablet
  • Instructions for extended release tablet
  • Use in renal impaired patient

Interaction

  • No chronic interaction with Furosemide
  • Interaction with Nifedipine
  • Potential interaction with cationic drugs
  • No effect on Cimetidine pharmacokinetics
  • List of drugs that may produce hyperglycemia

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia
  • Acute or chronic diseases affecting renal function

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities
  • Skin reactions

Pregnancy & Lactation

  • Risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
  • Recommendation against using metformin during pregnancy
  • Excretion of metformin into human breast milk
  • No adverse effects observed in breastfed newborns/infants

Precautions & Warnings

  • Substantial excretion by the kidney
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia in combination therapy
  • Regular monitoring of renal function
  • Temporary discontinuation before surgery and clinical investigations
  • Caution in conditions causing dehydration or serious infections
  • Annual estimation of Vitamin B-12 levels
  • Potential interaction with anticoagulants

Use in Special Populations

  • Dosage adjustment based on renal function in elderly subjects
  • No effect on growth and puberty detected in controlled clinical studies
  • Careful follow-up on the effect of metformin on children
  • Particular caution in prescribing to children aged between 10 and 12 years
  • Recommendation for regular renal function assessment
  • Caution in situations where renal function may become impaired

Overdose Effects

  • Absence of hypoglycemia with up to 85 gm doses
  • Occurrence of lactic acidosis in overdose circumstances
  • Lactic acidosis as a medical emergency
  • Treatment of lactic acidosis via hemodialysis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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