Meglu ER 750 mg (Tablet (Extended Release))
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management in overweight patients
- Monotherapy or combination therapy
- Reduction of diabetic complications
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
Dosage & Administration
- Dosage individualized based on effectiveness and tolerance
- Usual starting dose for adults 500 mg twice a day
- Usual starting dose for children 500 mg twice a day
- Dosage increases in increments of 500 mg or 850 mg
- Maximum recommended daily doses
Interaction
- No chronic co-administration information with Furosemide
- Enhancement of absorption with Nifedipine
- Potential interaction with cationic drugs
- Certain drugs producing hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities
- Recommendation to use insulin during pregnancy
- Excretion into human breast milk
- No adverse effects observed in breastfed newborns/infants
Precautions & Warnings
- Excretion by the kidney
- Risk of lactic acidosis
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia
- Regular monitoring of renal function
- Stabilization of diabetic patients with Meglu ER and insulin
Use in Special Populations
- Adjustment of metformin dosage in elderly subjects
- Confirmation of type 2 diabetes mellitus before treatment initiation
- No effect on growth and puberty detected in controlled clinical studies
- Recommendation for careful follow-up in metformin-treated children
Overdose Effects
- No hypoglycemia seen with Meglu ER doses up to 85 gm
- Occurrence of lactic acidosis in such circumstances
- Medical emergency requiring treatment in hospital
- Effective removal by hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children