Meglu ER 1000 mg (Tablet (Extended Release))
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes mellitus in overweight patients
- Monotherapy for adults with type 2 diabetes mellitus
- Combination therapy for adults with type 2 diabetes mellitus
- Combination therapy for children from 10 years of age and adolescents with type 2 diabetes mellitus
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers both basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Metformin immediate release tablet
- Metformin extended release tablet
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Dosage increments for adults and children
- Swallow Metformin XR tablet whole and never crush, cut, or chew
Interaction
- No information available about the interaction of Meglu ER and Furosemide
- Nifedipine appears to enhance the absorption of Meglu ER
- Minimal effects of Meglu ER on Nifedipine
- Potential interaction with cationic drugs eliminated by renal tubular secretion
- No effect on Cimetidine pharmacokinetics
- Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
- Metformin excreted into human breast milk
- No adverse effects observed in breastfed newborns/infants
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of lactic acidosis increases with impaired renal function
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia when used in combination with insulin
- Regular monitoring of renal function advised
- Therapy cessation before surgery and reinstatement after renal function regain
- Caution in conditions causing dehydration, serious infections, or trauma
- Annual estimation of Vitamin B-12 levels for patients on continuous therapy
- Stabilization of diabetic patients with Meglu ER and insulin should be carried out in hospital
Use in Special Populations
- Dosage adjustment in elderly subjects based on renal function
- Confirmation of type 2 diabetes mellitus before treatment initiation in pediatric population
- No effect of metformin on growth and puberty detected during controlled clinical studies
- Regular assessment of renal function for patients of all age groups
- Caution in conditions where renal function may become impaired
Overdose Effects
- No hypoglycemia seen with Meglu ER doses up to 85 gm
- Lactic acidosis seen in overdose circumstances
- Hemodialysis as the most effective method to remove lactate and Meglu ER
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children