Meglu ER 1000 mg (Tablet (Extended Release))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Unimed unihealth pharmaceuticals ltd
Also available as
Meglu 500 mg tablet Meglu 850 mg tablet Meglu er 500 mg tablet Meglu er 750 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes mellitus in overweight patients
  • Monotherapy for adults with type 2 diabetes mellitus
  • Combination therapy for adults with type 2 diabetes mellitus
  • Combination therapy for children from 10 years of age and adolescents with type 2 diabetes mellitus

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers both basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Metformin immediate release tablet
  • Metformin extended release tablet
  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Dosage increments for adults and children
  • Swallow Metformin XR tablet whole and never crush, cut, or chew

Interaction

  • No information available about the interaction of Meglu ER and Furosemide
  • Nifedipine appears to enhance the absorption of Meglu ER
  • Minimal effects of Meglu ER on Nifedipine
  • Potential interaction with cationic drugs eliminated by renal tubular secretion
  • No effect on Cimetidine pharmacokinetics
  • Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Taste disturbance
  • Gastrointestinal disorders
  • Liver function test abnormalities or hepatitis
  • Skin reactions

Pregnancy & Lactation

  • Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
  • Metformin excreted into human breast milk
  • No adverse effects observed in breastfed newborns/infants
  • Breastfeeding not recommended during metformin treatment

Precautions & Warnings

  • Substantial excretion by the kidney
  • Risk of lactic acidosis increases with impaired renal function
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia when used in combination with insulin
  • Regular monitoring of renal function advised
  • Therapy cessation before surgery and reinstatement after renal function regain
  • Caution in conditions causing dehydration, serious infections, or trauma
  • Annual estimation of Vitamin B-12 levels for patients on continuous therapy
  • Stabilization of diabetic patients with Meglu ER and insulin should be carried out in hospital

Use in Special Populations

  • Dosage adjustment in elderly subjects based on renal function
  • Confirmation of type 2 diabetes mellitus before treatment initiation in pediatric population
  • No effect of metformin on growth and puberty detected during controlled clinical studies
  • Regular assessment of renal function for patients of all age groups
  • Caution in conditions where renal function may become impaired

Overdose Effects

  • No hypoglycemia seen with Meglu ER doses up to 85 gm
  • Lactic acidosis seen in overdose circumstances
  • Hemodialysis as the most effective method to remove lactate and Meglu ER

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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