Meth 2.5 mg (Tablet)

Unit Price: ৳ 4.00 (2 x 14: ৳ 112.00)

Strip Price: ৳ 56.00

Medicine Details

Category	Details
Generic	Methotrexate
Company	Drug international ltd
Also available as	Meth 10 mg tablet

Indications

Treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole
Treatment of acute lymphoblastic leukemia
Management of severe, active rheumatoid arthritis
Symptomatic control of severe, recalcitrant, disabling psoriasis

Pharmacology

Inhibits dihydrofolic acid reductase
Interferes with DNA synthesis, repair, and cellular replication

Dosage

Orally or intramuscularly in doses of 15 to 30 mg daily for a five-day course for choriocarcinoma and similar trophoblastic diseases
Induction dose: 3.3 mg/m2 in combination with prednisone 60 mg/m2 daily for 4 to 6 weeks for acute lymphoblastic leukemia
Single doses of 7.5 mg once per week for adult rheumatoid arthritis

Administration

Should be taken on an empty stomach. May be taken with meals to reduce GI discomfort. Avoid taking with milk-rich products.

Interaction

NSAIDs: Should not be administered prior to or concomitantly with high doses of Methotrexate
Salicylates, Phenylbutazone, Phenytoin and Sulfonamides may increase toxicity
Cisplatin: Caution must be exercised if high-dose Methotrexate is administered in combination
Vitamin preparations containing folic acid or its derivatives decreases responses to systemically administered Methotrexate

Contraindications

Alcoholism, alcoholic liver disease or other chronic liver disease
Immunodeficiency syndromes
Hypersensitivity to methotrexate
Pregnant women with psoriasis or rheumatoid arthritis

Side Effects

Ulcerative stomatitis
Leukopenia
Nausea and abdominal distress
Impairment of fertility, oligospermia, and menstrual dysfunction

Pregnancy & Lactation

US FDA Pregnancy Category X. Methotrexate should be used in the treatment of neoplastic diseases only when the potential benefit outweighs the risk to the fetus. It is contraindicated in nursing mothers.

Precautions & Warnings

Meth formulations and diluents containing preservatives must not be used for intrathecal or high dose Methotrexate therapy
Follow patients on Methotrexate closely for toxic effects
Persistent liver function test abnormalities & depression of serum albumin may be indicators of serious liver toxicity

Use in Special Populations

Benefits should be weighed against the potential risk before using Methotrexate in pediatric patients
Elderly patients should be closely monitored for early signs of hepatic, bone marrow, and renal toxicity

Overdose Effects

Leucovorin is indicated to diminish the toxicity and counteract the effect of inadvertently administered overdosages of Methotrexate

Therapeutic Class

Antidote preparations, Immunosuppressant

Storage Conditions

Store at a temperature not exceeding 30°C in a dry place. Protect from light & moisture