Pramax 20 mg (Tablet (Enteric Coated))

Indications

• Peptic ulcer diseases
• Gastroesophageal reflux diseases
• Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
• Eradication of Helicobacter pylori (in combination with antibiotics)
• Zollinger-Ellison Syndrome

Pharmacology

• Proton pump inhibitor
• Suppresses gastric acid production
• Covalently binds to H+/K+ ATPase enzyme system
• Inhibits both basal and stimulated gastric acid secretion

Dosage and administration

• Dosage for benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed
• Dosage for gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed
• Dosage for duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed
• Dosage for duodenal ulcer associated with Helicobacter pylori: 40 mg twice daily in combination with antibiotics for one week
• Dosage for prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily
• Dosage for Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response, with a maximum of 40 mg daily for elderly patients

Interaction

• No significant drug interactions observed in clinical studies

Contraindications

• Not for use in patients with known hypersensitivity to any of the components

Side effects

• Common side effects: Headache, diarrhea
• Rare side effects: Abdominal pain, flatulence, rash, insomnia, hyperglycemia

Pregnancy and lactation

• Category B for pregnancy
• Excreted in human milk
• Use during pregnancy only if clearly needed

Precautions and warnings

• Tablet should not be split, chewed or crushed
• Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12)
• Increased risk of osteoporosis related disorders

Overdose effects

• No known symptoms of overdosage in humans
• Not readily dialyzable
• No specific therapy recommended

Therapeutic class

• Proton Pump Inhibitor

Reconstitution

• IV injection should be given as a slow intravenous injection
• Reconstituted solution may be stored at room temperature for a maximum of 4 hours
• IV infusion should be given over a period of approximately 15 minutes
• Reconstituted solution may be stored at room temperature for a maximum of 4 hours prior to further dilution

Storage conditions

• Keep in a dry place, away from light and heat
• Keep out of the reach of children

Chemical structure

• Molecular Formula: C16H15F2N3O4S
• Chemical Structure available

Common questions

• What is Pramax 20 mg Tablet?
• How long do I need to use Pramax 20 mg Tablet before I see improvement in my condition?
• At what frequency do I need to use Pramax 20 mg Tablet?
• Should I use Pramax 20 mg Tablet empty stomach, before food or after food?
• What are the instructions for the storage and disposal of Pramax 20 mg Tablet?
• What are the effects of Pramax 20 mg Tablet on older adults?
• How long does it take for Pramax 20 mg Tablet to work?
• Is Pramax 20 mg Tablet safe?
• Does Pramax 20 mg Tablet cause weight gain?
• What are the side effects of Pramax 20 mg Tablet?
• Can I take Pramax 20 mg Tablet if I am pregnant or breastfeeding?
• What should I do if I miss a dose of Pramax 20 mg Tablet?

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