Sardopa 500 mg (Tablet)
Unit Price: ৳ 5.90 (2 x 14: ৳ 165.20)
Strip Price: ৳ 82.60
Medicine Details
| Category | Details |
|---|---|
| Generic | Methyldopa |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
Pharmacology
- Centrally acting sympatholytic agent
- Antihypertensive agent
- Prodrug
- Alpha-2 adrenergic receptors agonist
- Reduction of vasoconstrictor adrenergic signals
- Available as intravenous injection
Dosage & Administration
- Usual starting dosage of 250 mg two or three times a day
- Maximum recommended daily dosage of 3 gm for adults
- Pediatric use based on 10 mg/kg of body weight daily
- Adjustment of other antihypertensive drugs doses when used concomitantly
Interaction
- Potentiation of antihypertensive effect when used with other antihypertensive drugs
- Careful monitoring for symptoms of lithium toxicity when used concomitantly with lithium
- Not recommended to be used concomitantly with ferrous sulfate or ferrous gluconate
Contraindications
- Active hepatic disease
- Liver disorders previously associated with Methyldopa therapy
- Hypersensitivity to any component of the product
- Undergoing therapy with monoamine oxidase (MAO) inhibitors
Side Effects
- Sedation
- Headache
- Asthenia
- Angina pectoris
- Congestive heart failure
- Orthostatic hypotension
- Edema or weight gain
- Bradycardia
- Pancreatitis
- Colitis
- Vomiting
- Diarrhea
- Nausea
- Constipation
- Dryness of mouth
- Hyperprolactinemia
- Bone marrow depression
- Leukopenia
- Hemolytic anemia
- Rheumatoid factor
- Hepatitis
- Jaundice
- Myocarditis
- Pericarditis
- Vasculitis
- Eosinophilia
- Parkinsonism
- Bell's palsy
- Nightmares
- Reversible mild psychoses or depression
- Dizziness
- Lightheadedness
- Paresthesias
- Arthralgia
- Myalgia
- Nasal stuffiness
- Rash
- Amenorrhea
- Gynecomastia
- Lactation
- Impotence
Pregnancy & Lactation
- Pregnancy category B
- Caution advised when given to nursing women
Precautions & Warnings
- Caution in patients with a history of previous liver disease or dysfunction
- Use of diuretic to control clinical edema or weight gain
- Discontinuation if edema progresses or signs of heart failure appear
- Recurrence of hypertension after dialysis
- Rare occurrence of involuntary choreoathetotic movements in severe bilateral cerebrovascular disease patients
Use in Special Populations
- No well-controlled clinical trials in pediatric patients
- Dosing in pediatric patients supported by evidence from published literature regarding the treatment of hypertension in pediatric patients
Overdose Effects
- Acute hypotension
- Excessive sedation
- Weakness
- Bradycardia
- Dizziness
- Constipation
- Distention
- Flatus
- Diarrhea
- Nausea
- Vomiting
- Employment of symptomatic and supportive measures in case of overdosage
- Gastric lavage or emesis to reduce absorption if ingestion is recent
- Infusions to promote urinary excretion if ingestion has been earlier
Therapeutic Class
- Centrally acting antihypertensive drugs (central sympatholytic)
Storage Conditions
- Do not store above 30°C
- Keep out of the reach of children