Prazolin 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 6.00 (50's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Pantoprazole sodium
Company Rephco pharmaceuticals ltd
Also available as
Prazolin 20 mg tablet

Indications

  • Peptic ulcer diseases
  • Gastroesophageal reflux diseases
  • Ulcer induced by NSAIDs
  • Eradication of Helicobacter pylori (in combination with antibiotics)
  • Zollinger-Ellison Syndrome

Pharmacology

Proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell, leading to inhibition of both basal and stimulated gastric acid secretion.

Dosage & Administration

  • Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed
  • Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily
  • Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed
  • Duodenal ulcer associated with Helicobacter pylori: 40 mg twice daily in association with antimicrobial agents for one week
  • Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for long-term NSAID treatment
  • Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response; daily doses above 80 mg given in 2 divided doses

Interaction

No significant drug interactions observed in clinical studies

Contraindications

Contraindicated in patients with known hypersensitivity to any of the components of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Abdominal pain
  • Flatulence
  • Rash
  • Insomnia
  • Hyperglycemia

Pregnancy & Lactation

US FDA Pregnancy Category B, not enough studies in pregnant woman, excreted in human milk, use during pregnancy only if clearly needed

Precautions & Warnings

  • Tablet should not be split, chewed or crushed
  • Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12) or increase the risk of osteoporosis related disorders

Overdose Effects

No known symptoms of overdosage in humans. Highly protein bound, not readily dialyzable.

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

  • IV injection: Slow intravenous injection; solution obtained by adding 0.9% Sodium Chloride Injection to the vial containing powder
  • IV infusion: Intravenous infusion over a period of approximately 15 minutes; reconstituted with 0.9% Sodium Chloride Injection and further diluted with 0.9% Sodium Chloride Injection or 5% Dextrose or Lactated Ringer's Injection

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

Chemical Structure

  • Molecular Formula: C16H15F2N3O4S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-859-pantoprazole-sodium-chemical-structure-cnfmhAVGwpLzfJYlfu9P.svg

Common Questions about Prazolin 40 mg Tablet

  • What is Prazolin 40 mg Tablet?
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  • How long does it take for Prazolin 40 mg Tablet to work?
  • Is Prazolin 40 mg Tablet safe?
  • Does Prazolin 40 mg Tablet cause weight gain?
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  • Can I take Prazolin 40 mg Tablet if I am pregnant or breastfeeding?
  • What should I do if I miss a dose of Prazolin 40 mg Tablet?

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