Depomed 80 mg/2 ml (Injection)
80 mg vial: ৳ 100.30 (1 x 3: ৳ 300.90)
Medicine Details
| Category | Details |
|---|---|
| Generic | Methylprednisolone acetate |
| Company | Drug international ltd |
| Also available as |
Indications
- Indicated in the treatment of asthma
- Treatment of atopic dermatitis
- Treatment of contact dermatitis
- Treatment of bullous dermatitis herpetiformis
- Treatment of mycosis fungoides
- Treatment of pemphigus
- Treatment of severe erythema multiforme
- Treatment of adrenocortical insufficiency
- Hypercalcemia associated with cancer treatment
- Treatment of nonsuppurative thyroiditis
- Treatment of ulcerative colitis
- Management of hematologic disorders
- Palliative management of leukemias and lymphomas
- Treatment of sympathetic ophthalmia
- Management of keratitis
- Treatment of allergic conjunctivitis
- Management of juvenile rheumatoid arthritis
- Treatment of ankylosing spondylitis
- Symptomatic management of sarcoidosis
- Treatment of aspiration pneumonitis
Pharmacology
- Binds to and activates intracellular glucocorticoid receptors
- Modifies transcription and protein synthesis
- Inhibits leukocyte infiltration
- Interferes with mediators of inflammatory response
- Suppresses humoral immune responses
- Involves phospholipase A2 inhibitory proteins
- Controls the biosynthesis of potent mediators of inflammation
Dosage & Administration
- Doses for intra-articular administration
- Dose variation based on the size of the joint
- Doses for various dermatological conditions
- Intramuscular injection dosage for adrenogenital syndrome
- Intramuscular dose for maintenance of rheumatoid arthritis
- Dose for dermatologic lesions benefited by systemic corticosteroid therapy
- Dose for acute severe dermatitis due to poison ivy
- Dose for chronic contact dermatitis
- Dose for seborrheic dermatitis
- Dose for asthmatic patients
- Dose for allergic rhinitis (hay fever)
- Dose for multiple sclerosis
- Effective dosage for acute exacerbations of multiple sclerosis
Interaction
- Reported convulsions with concurrent use of methylprednisolone and cyclosporine
- Hepatic enzyme induction with concurrent use of certain drugs
- Inhibition of metabolism and decreased clearance with certain drugs
- Increased clearance of chronic high dose aspirin
- Reports of enhanced or diminished effects of anticoagulants when given concurrently with corticosteroids
Contraindications
- Contraindicated for intrathecal administration
- Contraindicated in systemic fungal infections
- Contraindicated in patients with known hypersensitivity to the product and its constituents
Side Effects
- Congestive heart failure in susceptible patients
- Hypertension
- Sodium retention
- Muscle weakness
- Osteoporosis
- Peptic ulcer with possible subsequent hemorrhage
- Abdominal distention
- Increased sweating
- Convulsion
- Vertigo
- Headache
- Menstrual irregularities
- Secondary adrenocortical and pituitary unresponsiveness
- Increased intraocular pressure
- Glaucoma
- Allergic or hypersensitivity reactions
- Urticaria
- Hyperpigmentation or hypopigmentation
Pregnancy & Lactation
- Pregnancy Category C
- Adequate human reproduction studies not done
- Use requires careful consideration of benefits and potential hazards
Precautions & Warnings
- Cautious use in patients with ocular herpes simplex
- Cautious use in patients with nonspecific ulcerative colitis
- Cautious use in patients with renal insufficiency
- Cautious use in patients with hypertension
- Cautious use in patients with osteoporosis
- Cautious use in patients with myasthenia gravis
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Store between 20-25˚ C