Depo-pred 40 mg/ml (Injection)
40 mg vial: ৳ 75.00 (1 x 3: ৳ 225.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Methylprednisolone acetate |
| Company | Ziska pharmaceuticals ltd |
Indications
- Asthma
- Atopic dermatitis
- Contact dermatitis
- Bullous dermatitis herpetiformis
- Mycosis fungoides
- Pemphigus
- Severe erythema multiforme
- Adrenocortical insufficiency
- Hypercalcemia associated with cancer
- Nonsuppurative thyroiditis
- Ulcerative colitis
- Hematologic disorders
- Leukemias
- Lymphomas
- Sympathetic ophthalmia
- Keratitis
- Allergic conjunctivitis
- Juvenile rheumatoid arthritis
- Ankylosing spondylitis
- Sarcoidosis
- Aspiration pneumonitis
Pharmacology
- Binds to and activates intracellular glucocorticoid receptors
- Modifies transcription and protein synthesis
- Inhibits leukocyte infiltration
- Interferes with mediators of inflammatory response
- Suppresses humoral immune responses
- Involves phospholipase A2 inhibitory proteins
- Controls the biosynthesis of inflammation mediators
Dosage & Administration
- Intra-articular administration for rheumatoid and osteoarthritis
- Dermatological conditions treatment
- Systemic effect administration
- Treatment of acute exacerbations of multiple sclerosis
- Dosage varies based on condition and severity
Interaction
- Convulsions reported with concurrent use of methylprednisolone and cyclosporine
- Drugs that induce hepatic enzymes may increase the clearance
- Some drugs may inhibit the metabolism and decrease clearance
- Reports of enhanced or diminished effects of anticoagulants when given concurrently with corticosteroids
Contraindications
- Intrathecal administration
- Systemic fungal infections
- Known hypersensitivity to the product and its constituents
Side Effects
- Congestive heart failure
- Hypertension
- Sodium retention
- Muscle weakness
- Osteoporosis
- Peptic ulcer with possible subsequent hemorrhage
- Abdominal distention
- Increased sweating
- Convulsion
- Vertigo
- Headache
- Menstrual irregularities
- Secondary adrenocortical and pituitary unresponsiveness
- Increased intraocular pressure
- Glaucoma
- Allergic or hypersensitivity reactions
- Urticaria
- Hyperpigmentation or hypopigmentation
Pregnancy & Lactation
- Pregnancy Category C
- Adequate human reproduction studies have not been done
- Use in pregnancy, nursing mothers, or women of childbearing potential requires careful consideration of benefits and potential hazards
Precautions & Warnings
- Use cautiously in patients with ocular herpes simplex
- Nonspecific ulcerative colitis
- Renal insufficiency
- Hypertension
- Osteoporosis
- Myasthenia gravis
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Store between 20-25° C