Methsolon 1 gm/vial (IM/IV Injection)

1 gm vial: ৳ 1,000.00

Medicine Details

Category Details
Generic Methylprednisolone sodium succinate
Company Incepta pharmaceuticals ltd
Also available as
Methsolon 500 mg injection

Indications

  • Endocrine disorders
  • Rheumatic disorders
  • Collagen diseases
  • Dermatological diseases
  • Allergic states
  • Ophthalmic diseases
  • Gastrointestinal diseases
  • Respiratory diseases
  • Hematologic disorders
  • Neoplastic diseases
  • Edematous state
  • Tuberculous meningitis
  • Trichinosis

Pharmacology

  • Naturally occurring glucocorticoid
  • Salt-retaining properties
  • Potent anti-inflammatory effects
  • Excretion within 12 hours
  • Influences carbohydrate, protein, and fat metabolism
  • Suppressive effect on the immune response

Dosage & Administration

  • Administration by IM or IV
  • Intravenous injection
  • High-dose therapy
  • Initial dosage varies from 10 to 40 mg
  • Dosage adjustments for pediatric patients
  • Dosage reduction or discontinuation gradual
  • Infusion over at least 30 minutes

Interaction

  • Aminoglutethimide interaction
  • Macrolide antibiotics interaction
  • Anticoagulants interaction
  • Antitubercular drugs interaction
  • Cyclosporine interaction
  • Ketoconazole interaction
  • Nonsteroidal anti-inflammatory agents interaction
  • Vaccines interaction

Contraindications

  • Systemic fungal infections
  • Intrathecal administration
  • Idiopathic thrombocytopenic purpura

Side Effects

  • Fluid and electrolyte disturbances
  • Musculoskeletal effects
  • Gastrointestinal effects
  • Dermatologic effects
  • Neurological effects
  • Endocrine effects
  • Ophthalmic effects
  • Other adverse reactions

Pregnancy & Lactation

  • Teratogenicity in many species
  • No adequate and well-controlled studies in pregnant women
  • Corticosteroids in human milk
  • Potential risk to the fetus
  • Suppression of growth in nursing infants

Precautions & Warnings

  • Sensitive to heat
  • Use lowest possible dose
  • Gradual reduction in dosage
  • Complications dependent on dose and duration of treatment
  • Discontinuation may result in clinical improvement

Use in Special Populations

  • Pediatric use
  • Decrease in growth velocity
  • Geriatric use
  • Cautious dose selection for elderly patients

Overdose Effects

  • Supportive and symptomatic therapy

Therapeutic Class

  • Glucocorticoids

Reconstitution

  • Directions for reconstitution
  • Aseptic addition of Water for Injection
  • Agitation to effect solution

Storage Conditions

  • Protect from light
  • Store at controlled room temperature
  • Use solution within 48 hours

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