Methsolon 500 mg/vial (IM/IV Injection)

500 mg vial: ৳ 600.00

Medicine Details

Category Details
Generic Methylprednisolone sodium succinate
Company Incepta pharmaceuticals ltd
Also available as
Methsolon 1 gm injection

Indications

  • Primary or secondary adrenocortical insufficiency
  • Acute adrenocortical insufficiency
  • Shock unresponsive to conventional
  • Congenital adrenal hyperplasia
  • Nonsuppurative thyroiditis
  • Rheumatoid arthritis
  • Acute and subacute bursitis
  • Psoriatic arthritis
  • Ankylosing spondylitis
  • Pemphigus
  • Severe erythema multiforme (Stevens-Johnson syndrome)
  • Severe seborrheic dermatitis
  • Ulcerative colitis (systemic therapy)
  • Pulmonary tuberculosis
  • Leukemias and lymphoma
  • Nephrotic syndrome
  • Tuberculous meningitis
  • Trichinosis
  • Sarcoidosis
  • Berylliosis
  • Idiopathic thrombocytopenic purpura
  • Edematous state
  • Multiple sclerosis

Pharmacology

  • Glucocorticoid
  • Anti-inflammatory effects
  • Salt-retaining properties
  • Potent anti-inflammatory effects in multiple organ systems
  • Rapid absorption when administered intramuscularly
  • Influences carbohydrate, protein, fat, and purine metabolism
  • Suppressive effect on the immune response

Dosage & Administration

  • Administered by IM or IV infusion
  • Administered intravenously over a period of several minutes
  • High dose therapy recommended in certain cases
  • Dosage may vary from 10 to 40 mg depending on the condition being treated
  • Reduction of dosage should be gradual
  • Dosage in pediatric patients varies depending on disease being treated
  • Intravenous infusion over at least 30 minutes for the treatment of acute exacerbations of multiple sclerosis

Interactions

  • Aminoglutethimide
  • Amphotericin B injection and potassium-depleting agents
  • Macrolide antibiotics
  • Anticholinesterases
  • Anticoagulants, oral
  • Antidiabetics
  • Antitubercular drugs
  • Cyclosporine
  • Digitalis glycosides
  • Estrogens, including oral contraceptives
  • Hepatic Enzyme Inhibitors
  • Ketoconazole
  • Nonsteroidal anti-inflammatory agents (NSAIDs)
  • Skin tests
  • Vaccines

Contraindications

  • Systemic fungal infections
  • Known hypersensitivity
  • Intrathecal administration
  • Idiopathic thrombocytopenic purpura

Side Effects

  • Fluid and electrolyte disturbances
  • Muscle weakness
  • Peptic ulcer with possible perforation and hemorrhage
  • Impaired wound healing
  • Increased intracranial pressure
  • Development of Cushingoid state
  • Posterior subcapsular cataracts
  • Negative nitrogen balance due to protein catabolism
  • Hyperpigmentation or hypopigmentation
  • Sterile abscess
  • Hypotension or hypertension

Pregnancy & Lactation

  • Corticosteroids shown to be teratogenic in many species
  • Corticosteroids appear in human milk
  • Potential for serious adverse reactions in nursing infants

Precautions & Warnings

  • Sensitive to heat
  • Lowest possible dose should be used
  • Reduction in dosage should be gradual
  • Discontinuation of corticosteroids may result in clinical improvement

Use in Special Populations

  • Adverse effects similar to those in adults in pediatric patients
  • Decrease in growth velocity in pediatric patients
  • No sufficient data for subjects aged 65 and over

Overdose Effects

  • Treatment by supportive and symptomatic therapy
  • Temporary reduction of dosage for chronic over dosage

Therapeutic Class

  • Glucocorticoids

Reconstitution

  • Directions for reconstitution
  • Removal of protective plastic flip-of seal
  • Cleansing stopper with a suitable germicide
  • Aseptic addition of water for injection
  • Agitation to effect solution
  • Insertion of needle through stopper for withdrawal of dose

Storage Conditions

  • Protection from light
  • Controlled room temperature 20 to 25°C
  • Use solution within 48 hours after mixing

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