Methsolon 500 mg/vial (IM/IV Injection)
500 mg vial: ৳ 600.00
Medicine Details
Category | Details |
---|---|
Generic | Methylprednisolone sodium succinate |
Company | Incepta pharmaceuticals ltd |
Also available as |
Indications
- Primary or secondary adrenocortical insufficiency
- Acute adrenocortical insufficiency
- Shock unresponsive to conventional
- Congenital adrenal hyperplasia
- Nonsuppurative thyroiditis
- Rheumatoid arthritis
- Acute and subacute bursitis
- Psoriatic arthritis
- Ankylosing spondylitis
- Pemphigus
- Severe erythema multiforme (Stevens-Johnson syndrome)
- Severe seborrheic dermatitis
- Ulcerative colitis (systemic therapy)
- Pulmonary tuberculosis
- Leukemias and lymphoma
- Nephrotic syndrome
- Tuberculous meningitis
- Trichinosis
- Sarcoidosis
- Berylliosis
- Idiopathic thrombocytopenic purpura
- Edematous state
- Multiple sclerosis
Pharmacology
- Glucocorticoid
- Anti-inflammatory effects
- Salt-retaining properties
- Potent anti-inflammatory effects in multiple organ systems
- Rapid absorption when administered intramuscularly
- Influences carbohydrate, protein, fat, and purine metabolism
- Suppressive effect on the immune response
Dosage & Administration
- Administered by IM or IV infusion
- Administered intravenously over a period of several minutes
- High dose therapy recommended in certain cases
- Dosage may vary from 10 to 40 mg depending on the condition being treated
- Reduction of dosage should be gradual
- Dosage in pediatric patients varies depending on disease being treated
- Intravenous infusion over at least 30 minutes for the treatment of acute exacerbations of multiple sclerosis
Interactions
- Aminoglutethimide
- Amphotericin B injection and potassium-depleting agents
- Macrolide antibiotics
- Anticholinesterases
- Anticoagulants, oral
- Antidiabetics
- Antitubercular drugs
- Cyclosporine
- Digitalis glycosides
- Estrogens, including oral contraceptives
- Hepatic Enzyme Inhibitors
- Ketoconazole
- Nonsteroidal anti-inflammatory agents (NSAIDs)
- Skin tests
- Vaccines
Contraindications
- Systemic fungal infections
- Known hypersensitivity
- Intrathecal administration
- Idiopathic thrombocytopenic purpura
Side Effects
- Fluid and electrolyte disturbances
- Muscle weakness
- Peptic ulcer with possible perforation and hemorrhage
- Impaired wound healing
- Increased intracranial pressure
- Development of Cushingoid state
- Posterior subcapsular cataracts
- Negative nitrogen balance due to protein catabolism
- Hyperpigmentation or hypopigmentation
- Sterile abscess
- Hypotension or hypertension
Pregnancy & Lactation
- Corticosteroids shown to be teratogenic in many species
- Corticosteroids appear in human milk
- Potential for serious adverse reactions in nursing infants
Precautions & Warnings
- Sensitive to heat
- Lowest possible dose should be used
- Reduction in dosage should be gradual
- Discontinuation of corticosteroids may result in clinical improvement
Use in Special Populations
- Adverse effects similar to those in adults in pediatric patients
- Decrease in growth velocity in pediatric patients
- No sufficient data for subjects aged 65 and over
Overdose Effects
- Treatment by supportive and symptomatic therapy
- Temporary reduction of dosage for chronic over dosage
Therapeutic Class
- Glucocorticoids
Reconstitution
- Directions for reconstitution
- Removal of protective plastic flip-of seal
- Cleansing stopper with a suitable germicide
- Aseptic addition of water for injection
- Agitation to effect solution
- Insertion of needle through stopper for withdrawal of dose
Storage Conditions
- Protection from light
- Controlled room temperature 20 to 25°C
- Use solution within 48 hours after mixing
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