Solupred 125 mg/vial (IM/IV Injection)

125 mg vial: ৳ 200.00

Medicine Details

Category Details
Generic Methylprednisolone sodium succinate
Company Ziska pharmaceuticals ltd
Also available as
Solupred 500 mg injection Solupred 1 gm injection

Indications

  • Primary or secondary adrenocortical insufficiency
  • Acute adrenocortical insufficiency
  • Shock unresponsive to conventional treatment
  • Congenital adrenal hyperplasia
  • Nonsuppurative thyroiditis
  • Rheumatoid arthritis
  • Juvenile rheumatoid arthritis
  • Acute and subacute bursitis
  • Psoriatic arthritis
  • Ankylosing spondylitis
  • Systemic lupus erythematosus
  • Pemphigus
  • Severe erythema multiforme
  • Severe seborrheic dermatitis
  • Controls bronchial asthma
  • Atopic dermatitis
  • Seasonal or perennial allergic rhinitis
  • Drug hypersensitivity reaction
  • Severe acute and chronic allergic and inflammatory processes involving the eye
  • Ulcerative colitis
  • Regional enteritis
  • Symptomatic sarcoidosis
  • Fulminating or disseminated pulmonary tuberculosis
  • Acquired (autoimmune) hemolytic anemia
  • Idiopathic thrombocytopenic purpura in adults
  • Leukemias and lymphoma
  • Inducing diuresis or remission of proteinuria in the nephrotic syndrome
  • Tuberculous meningitis
  • Trichinosis with neurologic or myocardial involvement

Pharmacology

  • Potent anti-inflammatory effects
  • Salt-retaining properties
  • Excretion within 12 hours
  • Influence on carbohydrate, protein, fat and purine metabolism
  • Exerts suppressive effect on the immune response

Dosage & Administration

  • May be administered by IM or IV or by IV infusion
  • Intravenously over a period of several minutes
  • High dose therapy
  • Dosage varies from 10 to 40 mg of Methylprednisolone
  • Dose must be decreased or discontinued gradually
  • Different initial dose for pediatric patients

Interactions

  • Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression
  • Amphotericin B injection and potassium-depleting agents
  • Macrolide antibiotics reported to cause a significant decrease in corticosteroid clearance
  • Anticholinesterases may produce severe weakness in patients with myasthenia gravis

Contraindications

  • Systemic fungal infections
  • Known hypersensitivity to the product and its constituents
  • Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura

Side Effects

  • Fluid and electrolyte disturbances
  • Muscle weakness
  • Peptic ulcer with possible perforation and hemorrhage
  • Impaired wound healing
  • Increased intraocular pressure
  • Negative nitrogen balance due to protein catabolism

Pregnancy & Lactation

  • Corticosteroids shown to be teratogenic in many species
  • Corticosteroids appear in human milk
  • Infants born to mothers who have received corticosteroids during pregnancy should be carefully observed

Precautions & Warnings

  • Should not be autoclaved
  • Lowest possible dose should be used
  • Discontinuation of corticosteroids may result in clinical improvement
  • Risk/benefit decision must be made for dose and duration of treatment

Use in Special Populations

  • Pediatric patients may experience a decrease in their growth velocity
  • Elderly patients may respond differently from younger subjects

Overdose Effects

  • Supportive and symptomatic therapy
  • Reduction of the corticosteroid dosage for chronic overdosage

Therapeutic Class

  • Glucocorticoids

Reconstitution

  • Directions for reconstitution provided

Storage Conditions

  • Protect from light
  • Store at controlled room temperature 20°C to 25°C
  • Use solution within 48 hours after mixing

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