Methipred 2 mg (Tablet)
Unit Price: ৳ 3.02 (4 x 15: ৳ 180.90)
Strip Price: ৳ 45.23
Medicine Details
| Category | Details |
|---|---|
| Generic | Methylprednisolone |
| Company | General pharmaceuticals ltd |
| Also available as |
Title
- Methipred 4mg Tablet
Categories
- Anti-inflammatory
- Immunosuppressant
- Glucocorticoid
Description
- Potent anti-inflammatory steroid
- Greater anti-inflammatory potency than Prednisolone
- Less tendency to induce sodium and water retention
Pharmacology
- Potent anti-inflammatory agent
- Profoundly inhibits the immune system
- Affects kidney, fluid & electrolyte balance, lipid, protein, and carbohydrate metabolism, skeletal muscle, cardiovascular system, immune system, nervous system, and endocrine system
Dosage administration
- Usual range of 2-48 mg daily in divided doses
- Initial dosage may vary from 4-48 mg per day
- Methylprednisolone 4 mg tablet can be used to treat and control severe allergy and dermatitis
- Alternate-day therapy for long-term treatment
Interaction
- Erythromycin, Clarithromycin, Phenobarbital, Phenytoin, Rifampin, and Ketoconazole inhibit the metabolism of Methipred
- Estrogens, including birth control pills, can increase the effect of corticosteroids
- Cyclosporin reduces the metabolism of Methipred, while Methipred reduces the metabolism of Cyclosporin
- Methipred may affect the effect of blood thinners (e.g. Warfarin)
Contraindications
- Systemic fungal infections
- Known hypersensitivity to components
Side effects
- Short courses are usually well-tolerated with few, mild side effects
- Long term, high doses may produce serious side effects
- Side effects range from mild annoyances to serious irreversible bodily damage
- Prolonged use can depress the body's adrenal glands' ability to produce corticosteroids
Pregnancy lactation
- Pregnancy category C
- Use in nursing mothers not adequately evaluated
Precautions warnings
- Adrenocortical insufficiency may persist after therapy discontinuation
- Enhanced effect on patients with hypothyroidism and cirrhosis
- Use cautiously in patients with ocular herpes simplex
- Aspirin use should be cautious in hypoprothrombinemia
- Careful observation of infants' and children's growth and development on prolonged therapy
Overdose effects
- Report of acute toxicity and/or death are rare following an overdose of glucocorticoid
- No specific antidote available
- Treatment is supportive and symptomatic
Therapeutic class
- Glucocorticoids
Storage conditions
- Store in a cool, dry place, away from light
- Keep out of reach of children
Indications
- Primary or Secondary Adrenocortical Insufficiency
- Rheumatoid Arthritis
- Bullous Dermatitis Herpetiformis
- Seasonal or Perennial Allergic Rhinitis
- Symptomatic sarcoidosis
Pharmacodynamic properties
- Potent anti-inflammatory agent
- Binds and activates intracellular glucocorticoid receptors
- Influences kidney and fluid & electrolyte balance
- Metabolized in the liver to inactive metabolites
Pharmacokinetic properties
- High bioavailability following oral administration
- Rapidly absorbed
- Widely distributed into the tissues
- Secreted in breast milk
- Metabolized in the liver to inactive metabolites
- Haemodializable
Neoplastic diseases
- Palliative management of Leukemias and Lymphomas in adults
- Acute leukemia of childhood
Respiratory diseases
- Loeffler's syndrome not manageable by other means
- Aspiration Pneumonitis
Allergy
- Drug hypersensitivity reactions
- Serum Sickness
- Contact Dermatitis
- Bronchial Asthma
- Atopic Dermatitis
Hematological disorders
- Idiopathic Thrombocytopenic Purpura in adults
- Acquired (Autoimmune) Hemolytic Anemia
Dermatologic diseases
- Severe Erythema Multiforme (Stevens-Johnson syndrome)
- Severe Seborrheic Dermatitis
- Pemphigus
- Severe Psoriasis
Endoctrine disorders
- Congenital Adrenal Hyperplasia
- Nonsuppurative Thyroiditis
- Hypercalcemia associated with Cancer
Rheumatic disorders
- Juvenile Rheumatoid Arthritis
- Ankylosing Spondylitis
- Acute and Subacute Bursitis
Collagen diseases
- Systemic lupus Erythematosus
- Systemic Dermatomyositis
Gastrointestinal disease
- Ulcerative Colitis
- Regional Enteritis
Cns disease
- Acute Exacerbations of Multiple Sclerosis
Edematous states
- Proteinuria in the Nephrotic Syndrome